T
Twee Tsao
Researcher at University of Texas MD Anderson Cancer Center
Publications - 25
Citations - 3601
Twee Tsao is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 19, co-authored 25 publications receiving 3397 citations. Previous affiliations of Twee Tsao include Hoffmann-La Roche.
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Journal ArticleDOI
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
Marina Konopleva,Rooha Contractor,Twee Tsao,Ismael Samudio,Peter P. Ruvolo,Peter P. Ruvolo,Shinichi Kitada,Xingming Deng,Dayong Zhai,Yue Xi Shi,Thomas Sneed,Monique Verhaegen,Maria S. Soengas,Vivian Ruvolo,Teresa McQueen,Wendy D. Schober,Julie C. Watt,Tilahun Jiffar,Xiaoyang Ling,Frank C. Marini,David Harris,Martin Dietrich,Zeev Estrov,James A. McCubrey,W. Stratford May,John C. Reed,Michael Andreeff +26 more
TL;DR: ABT-737 effectively kills acute myeloid leukemia blast, progenitor, and stem cells without affecting normal hematopoietic cells, suggesting that ABT- 737 could be a highly effective antileukemia agent when the mechanisms of resistance identified here are considered.
Journal ArticleDOI
MicroRNA 29b functions in acute myeloid leukemia.
Ramiro Garzon,Catherine E. A. Heaphy,Violaine Havelange,Muller Fabbri,Stefano Volinia,Twee Tsao,Nicola Zanesi,Steven M. Kornblau,Guido Marcucci,George A. Calin,Michael Andreeff,Carlo M. Croce +11 more
TL;DR: The data support a tumor suppressor role for miR-29 and provide a rationale for the use of synthetic mi R-29b oligonucleotides as a novel strategy to improve treatment response in AML.
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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.
Kensuke Kojima,Marina Konopleva,Marina Konopleva,Ismael Samudio,Ismael Samudio,Masato Shikami,Masato Shikami,Maria Cabreira-Hansen,Maria Cabreira-Hansen,Teresa McQueen,Teresa McQueen,Vivian Ruvolo,Vivian Ruvolo,Twee Tsao,Twee Tsao,Zhihong Zeng,Zhihong Zeng,Lyubomir T. Vassilev,Lyubomir T. Vassilev,Michael Andreeff,Michael Andreeff +20 more
TL;DR: No induction of apoptosis was observed in AML samples harboring mutant p53, and p53 activation by targeting the p53-MDM2 interaction might offer a novel therapeutic strategy for AML that retain wild-type p53.
Journal ArticleDOI
Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)
Marina Konopleva,Julie C. Watt,Rooha Contractor,Twee Tsao,David Harris,Zeev Estrov,William G. Bornmann,Hagop M. Kantarjian,Jean Viallet,Ismael Samudio,Michael Andreeff +10 more
TL;DR: It is shown that obatoclax potently induces apoptosis and decreases leukemia cell proliferation and may be used in a novel therapeutic strategy for AML alone and in combination with other targeted agents and chemotherapeutics.
Journal ArticleDOI
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia
Marina Konopleva,Twee Tsao,Peter P. Ruvolo,Irina Stiouf,Zeev Estrov,Clinton E. Leysath,Shourong Zhao,David J. Harris,Shirong Chang,C. Ellen Jackson,Mark F. Munsell,Nanjoo Suh,Gordon W. Gribble,Tadashi Honda,W. Stratford May,Michael B. Sporn,Michael Andreeff +16 more
TL;DR: CDDO-Me is an MDR-1- and a p53-independent compound that exerts strong antiproliferative, apoptotic, and differentiating effects in myeloid leukemic cell lines and in primary AML samples when given in submicromolar concentrations.