MicroRNA 29b functions in acute myeloid leukemia.
Ramiro Garzon,Catherine E. A. Heaphy,Violaine Havelange,Muller Fabbri,Stefano Volinia,Twee Tsao,Nicola Zanesi,Steven M. Kornblau,Guido Marcucci,George A. Calin,Michael Andreeff,Carlo M. Croce +11 more
Reads0
Chats0
TLDR
The data support a tumor suppressor role for miR-29 and provide a rationale for the use of synthetic mi R-29b oligonucleotides as a novel strategy to improve treatment response in AML.About:
This article is published in Blood.The article was published on 2009-12-17 and is currently open access. It has received 448 citations till now. The article focuses on the topics: Myeloid leukemia & Leukemia.read more
Citations
More filters
Journal ArticleDOI
Causes and consequences of microRNA dysregulation in cancer
TL;DR: Because malignant cells show dependence on the dysregulated expression of miRNA genes, which in turn control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for the development of future miRNA-based therapies.
Journal ArticleDOI
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
Marilena V. Iorio,Carlo M. Croce +1 more
TL;DR: Current knowledge about the involvement of microRNAs in cancer, and their potential as diagnostic, prognostic and therapeutic tools are reviewed.
Journal ArticleDOI
Targeting microRNAs in cancer: rationale, strategies and challenges.
TL;DR: The role of miRNAAs in tumorigenesis is described and the rationale, the strategies and the challenges for the therapeutic targeting of miRNAs in cancer are critically discussed.
Journal ArticleDOI
MicroRNAs in development and disease.
Danish Sayed,Maha Abdellatif +1 more
TL;DR: The discovery, structure, and mode of function of miRNAs in mammalian cells are described, before elaborating on their roles and significance during development and pathogenesis in the various mammalian organs, while attempting to reconcile their functions with the existing knowledge of their targets.
Journal ArticleDOI
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
TL;DR: Progress in using mouse models to understand the roles ofmiRNAs in cancer and the potential for manipulating miRNAs for cancer therapy as these molecules make their way towards clinical trials are discussed.
References
More filters
Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Glynn Dennis,Brad T. Sherman,Douglas A. Hosack,Jun Jun Yang,Wei Gao,H. Clifford Lane,Richard A. Lempicki +6 more
TL;DR: DAMID is a web-accessible program that integrates functional genomic annotations with intuitive graphical summaries that assists in the interpretation of genome-scale datasets by facilitating the transition from data collection to biological meaning.
Journal Article
An international system for human cytogenetic nomenclature
TL;DR: An exceptional reading e-book entitled International System For Human Cytogenetic Nomenclature provides a thorough legal analysis and guidance to state authorities, human rights and humanitarian actors and others.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Related Papers (5)
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
George A. Calin,Manuela Ferracin,Manuela Ferracin,Amelia Cimmino,Gianpiero Di Leva,Masayoshi Shimizu,Sylwia E. Wojcik,Marilena V. Iorio,Rosa Visone,Nurettin Ilfer Sever,Muller Fabbri,Muller Fabbri,Rodolfo Iuliano,Tiziana Palumbo,Flavia Pichiorri,Claudia Roldo,Ramiro Garzon,Cinzia Sevignani,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Carlo M. Croce +24 more
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more