U
Umberto Fascio
Researcher at University of Milan
Publications - 53
Citations - 1590
Umberto Fascio is an academic researcher from University of Milan. The author has contributed to research in topics: Antigen & Nanotoxicology. The author has an hindex of 25, co-authored 53 publications receiving 1484 citations. Previous affiliations of Umberto Fascio include National Cheng Kung University.
Papers
More filters
Journal ArticleDOI
Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes
Federica Piccioni,Paolo Pinton,Silvia Simeoni,Paola Pozzi,Umberto Fascio,Guglielmo Vismara,Luciano Martini,Rosario Rizzuto,Angelo Poletti +8 more
TL;DR: Data suggest that neuropil aggregates may physically alter neurite transport and thus deprive neuronal processes of factors or components that are important for axonal and dendritic functions, leading to neuronal dysfunctions and possibly to cell death.
Journal ArticleDOI
Human Fetal Aorta Contains Vascular Progenitor Cells Capable of Inducing Vasculogenesis, Angiogenesis, and Myogenesis in Vitro and in a Murine Model of Peripheral Ischemia
Gloria Invernici,Costanza Emanueli,Paolo Madeddu,Silvia Cristini,Sergio Domenico Gadau,Anna Benetti,Emilio Ciusani,Giorgio Stassi,Mauro Siragusa,Roberto F. Nicosia,Cesare Peschle,Umberto Fascio,Augusto Colombo,Tommaso Rizzuti,Eugenio Parati,Giulio Alessandri +15 more
TL;DR: The identification of a population of vascular progenitor cells (hVPCs) in the human fetal aorta composed of undifferentiated mesenchymal cells that coexpress endothelial and myogenic markers is reported.
Journal ArticleDOI
Dendritic cell presentation of antigens from apoptotic cells in a proinflammatory context: Role of opsonizing anti–β2‐glycoprotein I antibodies
Patrizia Rovere,Maria Grazia Sabbadini,Cristina Vallinoto,Umberto Fascio,Maria Rescigno,Mariacristina Crosti,Paola Ricciardi-Castagnoli,Genesio Balestrieri,Angela Tincani,Angelo A. Manfredi +9 more
TL;DR: Opsonization influences the outcome of the disposal of low numbers of apoptotic cells by DCs, which implies that soluble factors bound to apoptotic Cells modulate their immunogenicity.
Journal ArticleDOI
Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells.
Patrizia Rovere,Maria Grazia Sabbadini,Cristina Vallinoto,Umberto Fascio,Valérie S. Zimmermann,Attilio Bondanza,Paola Ricciardi-Castagnoli,Angelo A. Manfredi +7 more
TL;DR: In vitro data suggesting that the number of apoptotic cells that die at a given time influences DC maturation and therefore their ability to uptake antigens from apoptotic Cells and cross‐activate T lymphocytes are discussed.
Journal ArticleDOI
The modality of cell–particle interactions drives the toxicity of nanosized CuO and TiO2 in human alveolar epithelial cells
Elisa Moschini,Maurizio Gualtieri,Miriam Colombo,Umberto Fascio,Marina Camatini,Paride Mantecca +5 more
TL;DR: The so-called "Trojan horse" mechanism and autophagy, are involved in nCuO-induced cell death, and associate their toxic effects with their cell penetration and interaction with various compartments.