Urs H. Langen

TL;DR: It is shown that Notch signalling in endothelial cells leads to the expansion of haematopoietic stem cell niches in bone, which involves increases in CD31-positive capillaries and platelet-derived growth factor receptor-β (PDGFRβ)-positive perivascular cells, arteriole formation and elevated levels of cellular stem cell factor.

TL;DR: Genetic experiments in postnatal mice show that the level of active Notch signalling is more important than the direct Dll4-mediated cell–cell communication between endothelial cells in controlling Notch-dependent vessel growth.

TL;DR: The development and cell biology of the blood-brain barrier is reviewed, focusing on the cellular and molecular regulation of barrier formation and the maintenance of the BBB through adulthood.

TL;DR: It is reported that embryonic and early postnatal long bone contains a specialized endothelial cell subtype, termed type E, which strongly supports osteoblast lineage cells and later gives rise to other endothelium cell subpopulations.

TL;DR: In this paper, the authors report the structure of a mouse MFSD2A and reveal its unique extracellular domain and substrate-binding cavity, which can be used to identify a conserved sodium-binding site and reveal a potential lipid entry pathway.