Benedetto Daniele Giaimo

TL;DR: Genetic experiments in postnatal mice show that the level of active Notch signalling is more important than the direct Dll4-mediated cell–cell communication between endothelial cells in controlling Notch-dependent vessel growth.

TL;DR: The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer.

TL;DR: The intracellular post-translational regulation of Notch that fine-tunes the outcome of the Notch response is reviewed and how crosstalk with other conserved signaling pathways like the Wnt, Hedgehog, hypoxia and TGFβ/BMP pathways can affect Notch signaling output is described.

TL;DR: In vivo analyses of the homologs of RBPJ and L3MBTL3 in Drosophila melanogaster and Caenorhabditis elegans demonstrate that the functional link between RBPj and L 3MB TL3 is evolutionarily conserved, thus identifying L3 MBTL3 as a universal modulator of Notch signaling in metazoans.

TL;DR: It is proposed that brain pericytes can acquire deleterious properties that actively enhance vascular lesion formation and promote pathogenic processes.