T
Tilman Borggrefe
Researcher at University of Giessen
Publications - 55
Citations - 2819
Tilman Borggrefe is an academic researcher from University of Giessen. The author has contributed to research in topics: Notch signaling pathway & Transcription factor. The author has an hindex of 23, co-authored 47 publications receiving 2241 citations. Previous affiliations of Tilman Borggrefe include Max Planck Society.
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Journal ArticleDOI
The Notch signaling pathway: transcriptional regulation at Notch target genes.
Tilman Borggrefe,Franz Oswald +1 more
TL;DR: Notch signaling is reviewed with a focus on gene regulatory events at Notch target genes, of utmost importance to understand Notch signaling since certain RBP-J associated cofactors and particular epigenetic marks determine the specificity of notch target gene expression in different cell types.
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Dll4 and Notch signalling couples sprouting angiogenesis and artery formation
Mara E. Pitulescu,Inga Schmidt,Benedetto Daniele Giaimo,Tobiah Antoine,Frank Berkenfeld,Francesca Ferrante,Hongryeol Park,Manuel Ehling,Daniel Biljes,Susana F. Rocha,Urs H. Langen,Martin Stehling,Takashi Nagasawa,Napoleone Ferrara,Tilman Borggrefe,Ralf H. Adams +15 more
TL;DR: Genetic experiments in postnatal mice show that the level of active Notch signalling is more important than the direct Dll4-mediated cell–cell communication between endothelial cells in controlling Notch-dependent vessel growth.
Journal ArticleDOI
The histone variant H2A.Z in gene regulation
Benedetto Daniele Giaimo,Francesca Ferrante,Andreas Herchenröther,Sandra B. Hake,Tilman Borggrefe +4 more
TL;DR: The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer.
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RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes
Franz Oswald,Michael Winkler,Ying Cao,Kathy Astrahantseff,Soizic Bourteele,Walter Knöchel,Tilman Borggrefe +6 more
TL;DR: It is functionally demonstrate that the SHARP repression domain is necessary and sufficient to repress transcription and that the absence of this domain causes a dominant negative Notch-like phenotype.
Journal ArticleDOI
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
Robert Liefke,Franz Oswald,Cristobal Alvarado,Dolores Ferres-Marco,Gerhard Mittler,Patrick Rodriguez,Maria Dominguez,Tilman Borggrefe +7 more
TL;DR: It is shown that the histone demethylase KDM5A is an integral, conserved component of Notch/RBP-J gene silencing, and interacts physically with RBP-J; this interaction is crucial for Notch-induced growth and tumorigenesis responses.