MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment
Adriaan H. de Wilde,V. Stalin Raj,Diede Oudshoorn,Theo M. Bestebroer,Stefan van Nieuwkoop,Ronald W. A. L. Limpens,Clara C. Posthuma,Yvonne van der Meer,Montserrat Bárcena,Bart L. Haagmans,Eric J. Snijder,Bernadette G. van den Hoogen +11 more
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TLDR
MERS- coV infection did not prevent the IFN-induced nuclear translocation of phosphorylated STAT1, in contrast to infection with SARS-CoV where this block inhibits the expression of antiviral genes, and this findings highlight relevant differences between these distantly related zoonotic CoVs in terms of their interaction with and evasion of the cellular innate immune response.Citations
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SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
Journal ArticleDOI
Therapeutic options for the 2019 novel coronavirus (2019-nCoV).
Guangdi Li,Erik De Clercq +1 more
TL;DR: The potential for repurposing existing antiviral agents to treat 2019-nCoV infection (now known as COVID-19) is discussed, some of which are already moving into clinical trials.
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Coronaviruses - drug discovery and therapeutic options.
TL;DR: The epidemiology, virology, clinical features and current treatment strategies of SARS and MERS are summarized, and the discovery and development of new virus-based and host-based therapeutic options for CoV infections are discussed.
Journal ArticleDOI
Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China.
Hua Su,Ming Yang,Cheng Wan,Li Xia Yi,Fang Tang,Hong Yan Zhu,Fan Yi,Haichun Yang,Agnes B. Fogo,Xiu Nie,Chun Zhang +10 more
TL;DR: In this paper, a detailed pathologic examination of kidney damage in critically ill patients with Coronavirus Disease 2019 (COVID-19) by light microscopy, ultrastructural observation and immunostaining was provided.
Journal ArticleDOI
Middle East respiratory syndrome.
TL;DR: The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012.
References
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Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Christian Drosten,Stephan Günther,Wolfgang Preiser,Sylvie van der Werf,H. R. Brodt,Stephan Becker,Holger F. Rabenau,Marcus Panning,Larissa Kolesnikova,Ron A. M. Fouchier,Annemarie Berger,Ana-Maria Burguière,Jindrich Cinatl,Markus Eickmann,Nicolas Escriou,Klaus Grywna,Stefanie Kramme,Jean-Claude Manuguerra,Stefanie Müller,Volker Rickerts,Martin Stürmer,Simon Vieth,Hans-Dieter Klenk,Albert D. M. E. Osterhaus,Herbert Schmitz,Hans Wilhelm Doerr +25 more
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI
A novel coronavirus associated with severe acute respiratory syndrome.
Thomas G. Ksiazek,Dean D. Erdman,Cynthia S. Goldsmith,Zaki,Teresa C. T. Peret,Shannon L. Emery,Suxiang Tong,Urbani C,James A. Comer,Wilina Lim,Pierre E. Rollin,Scott F. Dowell,Ai Ee Ling,Charles D. Humphrey,Wun-Ju Shieh,Jeannette Guarner,Christopher D. Paddock,Paul A. Rota,Barry S. Fields,Joseph L. DeRisi,Jyh-Yuan Yang,Nancy J. Cox,James M. Hughes,James W. LeDuc,William J. Bellini,Larry J. Anderson +25 more
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Journal ArticleDOI
Bats are natural reservoirs of SARS-like coronaviruses.
Wendong Li,Zhengli Shi,Meng Yu,Wuze Ren,Craig Smith,Jonathan H. Epstein,Hanzhong Wang,Gary Crameri,Zhihong Hu,Huajun Zhang,Jianhong Zhang,Jennifer A. McEachern,Hume Field,Peter Daszak,Bryan T. Eaton,Shuyi Zhang,Lin-Fa Wang +16 more
TL;DR: It is reported that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak, and these viruses display greater genetic variation than SARS-CoV isolated from humans or from civets.
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