V
Valentin Wittmann
Researcher at University of Konstanz
Publications - 129
Citations - 3199
Valentin Wittmann is an academic researcher from University of Konstanz. The author has contributed to research in topics: Glycosyl & Glycoprotein. The author has an hindex of 32, co-authored 125 publications receiving 2900 citations. Previous affiliations of Valentin Wittmann include Russian Academy of Sciences & Technische Universität München.
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Preparation and Transmetallation of a Triphenylstannyl β-D-Glucopyranoside: A highly stereoselective route to β-D-C-glycosides via glycosyl dianions
TL;DR: The triphenylstannyl β-D-glucopyranoside 4 was synthesized in one step from the 1,2-anhydro-α-Dglucophyranose 3 with (triphenyl stannyl)lithium as mentioned in this paper.
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Structural Comparison of Oligoribonucleotides and Their 2′-Deoxy-2′-fluoro Analogs by heteronuclear NMR spectroscopy
Bernd Reif,Valentin Wittmann,Harald Schwalbe,Christian Griesinger,Karlheinz Wörner,Kerstin Jahn-Hofmann,Joachim W. Engels,Wolfgang Bermel +7 more
TL;DR: It turns out that the fluorinated oligonucleotide exists in a 14:3 equilibrium between a hairpin and a duplex conformation, in contrast to the unmodified oligon nucleotide which predominantly adopts the hairpin conformation.
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Carbamate-linked lactose: design of clusters and evidence for selectivity to block binding of human lectins to (neo)glycoproteins with increasing degree of branching and to tumor cells.
Sabine André,Daniel Specker,Nicolai V. Bovin,Martin Lensch,Herbert Kaltner,Hans-Joachim Gabius,Valentin Wittmann +6 more
TL;DR: The reported bioactivity and the delineation of its modulation by structural parameters of lectins and glycans set instructive examples for the further design of selective inhibitors and assay procedures.
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Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels–Alder reactions
Anne-Katrin Späte,Verena F. Schart,Julia Häfner,Andrea Niederwieser,Thomas U. Mayer,Valentin Wittmann +5 more
TL;DR: Whereas the previously reported cyclopropene-labeled N-acylmannosamine derivative leads to significantly higher fluorescence staining of cell-surface glycoconjugates, the glucosamines derivative gave higher labeling efficiency with protein preparations containing also intracellular proteins.
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Unexpected formation of complex bridged tetrazoles via intramolecular 1,3-dipolar cycloaddition of 1,2-O-cyanoalkylidene derivatives of 3-azido-3-deoxy-d-allose
Marco Worch,Valentin Wittmann +1 more
TL;DR: Of the studied molecules, 3-azido-1,2-O-cyanoethylidene-3-deoxy-allopyranose provides the most suitable scaffold for intramolecular [2+3] cycloaddition under exceptionally mild conditions.