V
Valentin Wittmann
Researcher at University of Konstanz
Publications - 129
Citations - 3199
Valentin Wittmann is an academic researcher from University of Konstanz. The author has contributed to research in topics: Glycosyl & Glycoprotein. The author has an hindex of 32, co-authored 125 publications receiving 2900 citations. Previous affiliations of Valentin Wittmann include Russian Academy of Sciences & Technische Universität München.
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Journal ArticleDOI
NMR Spectroscopic Determination of the Solution Structure of a Branched Nucleic Acid from Residual Dipolar Couplings by Using Isotopically Labeled Nucleotides
Bernd N.M. van Buuren,Jiirgen Schleucher,Valentin Wittmann,Christian Griesinger,Harald Schwalbe,Sybren S. Wijmenga +5 more
TL;DR: NMR spectroscopic determination of the solution structure of a branched nucleic acid from residual dipolar couplings by using isotopically labeled nucleotides.
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clickECM: Development of a cell-derived extracellular matrix with azide functionalities.
Sybil Mara Ruff,Silke Keller,Daniel E. Wieland,Valentin Wittmann,Günter E. M. Tovar,Günter E. M. Tovar,Monika Bach,Monika Bach,Petra J. Kluger,Petra J. Kluger +9 more
TL;DR: It will be possible to create and investigate new clickECM materials with tunable bioactive properties and additional functionalities, which offers a promising approach for basic and applied research in the field of biomaterial science, biomedical applications, and tissue engineering.
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Triple Orthogonal Labeling of Glycans by Applying Photoclick Chemistry
Verena F. Schart,Jessica Hassenrück,Anne-Katrin Späte,Jeremias E. G. A. Dold,Raphael Fahrner,Valentin Wittmann +5 more
TL;DR: It is reported that the nitrile imine–alkene cycloaddition (photoclick reaction) is a suitable ligation reaction in MGE and for the first time, it is able to triply label glycans by a combination of DAinv, photoclick, and copper‐free click chemistry.
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Exploring the Potential of Norbornene-Modified Mannosamine Derivatives for Metabolic Glycoengineering.
Anne-Katrin Späte,Jeremias E. G. A. Dold,Ellen Batroff,Verena F. Schart,Daniel E. Wieland,Oliver R. Baudendistel,Valentin Wittmann +6 more
TL;DR: Two norbornenes‐modified mannosamine derivatives that differ in the stereochemistry at the norbornene (exo/endo linkage) are synthesized andKinetic investigations revealed that the exo derivative reacts more than twice as rapidly as the endo derivative.
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High-affinity multivalent wheat germ agglutinin ligands by one-pot click reaction.
TL;DR: Molecular modeling studies, in which the chitobiose moieties were fitted into crystallographically determined binding sites of WGA, correlate the binding enhancements of the multivalent ligands with their ability to bind to the protein in a chelating mode, finding the best WGA ligand a trivalent cluster with an IC50 value of 220 nM.