Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response
H. Sophie Knobloch,Alexandre Charlet,Lena C. Hoffmann,Marina Eliava,Sergey Khrulev,Ali Cetin,Pavel Osten,Martin K. Schwarz,Peter H. Seeburg,Ron Stoop,Valery Grinevich +10 more
TLDR
In vivo, local blue-light-induced endogenous OT release robustly decreased freezing responses in fear-conditioned rats and demonstrates that OT release from local axonal endings can specifically control region-associated behaviors.About:
This article is published in Neuron.The article was published on 2012-02-09 and is currently open access. It has received 873 citations till now. The article focuses on the topics: Forebrain & Oxytocin.read more
Citations
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From circuits to behaviour in the amygdala
Patricia H. Janak,Kay M. Tye +1 more
TL;DR: The amygdala has long been associated with emotion and motivation, playing an essential part in processing both fearful and rewarding environmental stimuli, and understanding how the amygdala contributes to a wide array of behaviours requires the study of distinct amygdala circuits.
Journal ArticleDOI
Neuronal circuits for fear and anxiety
TL;DR: This Review focuses on studies that have used circuit-based approaches to gain a more detailed, and also more comprehensive and integrated, view on how the brain governs fear and anxiety and how it orchestrates adaptive defensive behaviours.
Journal ArticleDOI
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
TL;DR: It is demonstrated that the rewarding properties of social interaction in mice require the coordinated activity of oxytocin and 5-HT in the nucleus accumbens, a mechanistic insight with implications for understanding the pathogenesis of social dysfunction in neuropsychiatric disorders such as autism.
From circuits to behaviour in the amygdala
Patricia H. Janak,Kay M. Tye +1 more
TL;DR: The amygdala has long been associated with emotion and motivation, playing an essential part in processing both fearful and rewarding environmental stimuli as mentioned in this paper, and with recent technological advances that allow for causal investigations of specific neural circuit elements, we can now begin to map the complex anatomical connections of the amygdala onto behavioural function.
Journal ArticleDOI
Deconstruction of a neural circuit for hunger
TL;DR: It is shown that AGRP neuron suppression of oxytocin neurons is critical for evoked feeding, revealing a new neural circuit that regulates hunger state and pathways associated with overeating disorders.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
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Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.
Georg Nagel,Tanjef Szellas,Wolfram Huhn,Suneel Kateriya,Nona Adeishvili,Peter Berthold,Doris Ollig,Peter Hegemann,Ernst Bamberg +8 more
TL;DR: It is demonstrated by functional expression, both in oocytes of Xenopus laevis and mammalian cells, that ChR2 is a directly light-switched cation-selective ion channel, and may be used to depolarize small or large cells, simply by illumination.
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