V
Vanessa Suckow
Researcher at Max Planck Society
Publications - 20
Citations - 1269
Vanessa Suckow is an academic researcher from Max Planck Society. The author has contributed to research in topics: Opitz G/BBB Syndrome & Mutation. The author has an hindex of 14, co-authored 19 publications receiving 1124 citations.
Papers
More filters
Journal ArticleDOI
MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation.
Alexander Trockenbacher,Vanessa Suckow,John Foerster,Jennifer Winter,Sybille Krauss,Hans-Hilger Ropers,Rainer Schneider,Susann Schweiger +7 more
TL;DR: It is shown that mutation of MID1 leads to a marked accumulation of the catalytic subunit of protein phosphatase 2A (PP2Ac), a central cellular regulator, which causes hypophosphorylation of MAPs, a pathological mechanism consistent with the OS phenotype.
Journal Article
Elevated Levels of Rad51 Recombination Protein in Tumor Cells
TL;DR: It is concluded that the increases in Rad51 protein and nuclear foci formation in tumor cells are the result of transcriptional up-regulation.
Journal ArticleDOI
The Opitz syndrome gene product, MID1, associates with microtubules
Susann Schweiger,John Foerster,T.J. Lehmann,Vanessa Suckow,Yves A. Muller,G. Walter,T. Davies,H. Porter,J.H.L.M. van Bokhoven,P. Lunt,P. Traub,Hans-Hilger Ropers +11 more
TL;DR: It is shown here that MID1 is a microtubule-associated protein that influences microtubules dynamics in MID1-overexpressing cells, and this observation is confirmed by demonstrating a colocalization of MID1 and tubulin in subcellular fractions and the association of endogenous MID1 withmicrotubules after in vitro assembly.
Journal ArticleDOI
Genetics of intellectual disability in consanguineous families
Hao Hu,Hao Hu,Kimia Kahrizi,Luciana Musante,Zohreh Fattahi,Ralf Herwig,Masoumeh Hosseini,Cornelia Oppitz,Seyedeh Sedigheh Abedini,Vanessa Suckow,Farzaneh Larti,Maryam Beheshtian,Bettina Lipkowitz,Tara Akhtarkhavari,Sepideh Mehvari,Sabine Otto,Marzieh Mohseni,Sanaz Arzhangi,Payman Jamali,Faezeh Mojahedi,Maryam Taghdiri,Elaheh Papari,Mohammad Javad Soltani Banavandi,Saeide Akbari,Seyed Hassan Tonekaboni,Hossein Dehghani,Mohammad Reza Ebrahimpour,Ingrid Bader,Behzad Davarnia,Monika Cohen,Hossein Khodaei,Beate Albrecht,Sarah Azimi,Birgit Zirn,Milad Bastami,Dagmar Wieczorek,Gholamreza Bahrami,Krystyna Keleman,Krystyna Keleman,Leila Nouri Vahid,Andreas Tzschach,Andreas Tzschach,Jutta Gärtner,Gabriele Gillessen-Kaesbach,Jamileh Rezazadeh Varaghchi,Bernd Timmermann,Fatemeh Pourfatemi,Aria Jankhah,Wei Chen,Pooneh Nikuei,Vera M. Kalscheuer,Morteza Oladnabi,Thomas F. Wienker,Hans-Hilger Ropers,Hossein Najmabadi +54 more
TL;DR: This study, the largest of its kind published to date, illustrates that high-throughput DNA sequencing in consanguineous families is a superior strategy for elucidating the thousands of hitherto unknown gene defects underlying AR-ID, and it sheds light on their prevalence.
Journal ArticleDOI
GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat
TL;DR: It is suggested that estrogen acts acutely at GPR30 in nociceptors to produce mechanical hyperalgesia.