Veerle Rottiers

TL;DR: Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that mi RNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.

TL;DR: The studies identify a conserved regulatory circuit in which SREBP-1 controls genes in the one-carbon cycle, which produces the methyl donor S-adenosylmethionine (SAMe), and suggest a feedback mechanism whereby maturation of nuclear, transcriptionally active SRE BP-1 is controlled by levels of PC.

TL;DR: A highly integrated microRNA-host gene circuit governing cholesterol/lipid metabolism and energy homeostasis in mammals that may have important therapeutic implications for the treatment of cardiometabolic disorders is revealed.

TL;DR: The findings demonstrate the efficacy and safety of an 8-mer LNA-antimiR against an miRNA family in a nonhuman primate metabolic disease model, suggesting that this could be a feasible approach for therapeutic targeting of miRNA families sharing the same seed sequence in human diseases.

TL;DR: The authors' statement is reproduced below, and the article has been corrected online.