V
Vera Boulay
Researcher at French Institute of Health and Medical Research
Publications - 8
Citations - 1073
Vera Boulay is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Thrombin & CD19. The author has an hindex of 8, co-authored 8 publications receiving 1015 citations.
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Journal ArticleDOI
Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells.
Jérôme Pène,Jean-François Gauchat,Sandrine Lécart,Elodie Drouet,Paul Guglielmi,Vera Boulay,Adriana Delwail,Don Foster,Jean-Claude Lecron,Hans Yssel +9 more
TL;DR: Results show that IL-21, in addition to promoting growth and differentiation of committed B cells, is a specific switch factor for the production of IgG1 and IgG3.
Journal ArticleDOI
Thrombin-Activated Human Endothelial Cells Support Monocyte Adhesion In Vitro Following Expression of Intercellular Adhesion Molecule-1 (ICAM-1; CD54) and Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106)
Gilles Kaplanski,Valérie Marin,Martine Fabrigoule,Vera Boulay,Anne-Marie Benoliel,Pierre Bongrand,S. Kaplanski,Catherine Farnarier +7 more
TL;DR: Results show that, in addition to selectins, thrombin directly induces a cytokine-independent expression of adhesion molecules of the Ig superfamily on HUVECs that may support firm leukocyte attachment during inflammation.
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The IL-6-Soluble IL-6Rα Autocrine Loop of Endothelial Activation as an Intermediate Between Acute and Chronic Inflammation: an Experimental Model Involving Thrombin
Valérie Marin,Felix A. Montero-Julian,Sandra Grès,Vera Boulay,Pierre Bongrand,Catherine Farnarier,Gilles Kaplanski +6 more
TL;DR: Thrombin-activated endothelium may induce a cascade of events characterized by IL-8 secretion, neutrophil local infiltration, and the release of IL-6Rα from neutrophils membranes, leading to a new cascade leading from acute to chronic inflammation.
Journal Article
Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression.
Gilles Kaplanski,M Fabrigoule,Vera Boulay,Charles A. Dinarello,Pierre Bongrand,S. Kaplanski,Catherine Farnarier +6 more
TL;DR: It is demonstrated that in addition to short term endothelial activation, thrombin also functions as a long acting proinflammatory agent by inducing endothelial synthesis of the mediators required for neutrophils activation and extravazation during inflammation.
Journal ArticleDOI
Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface.
Sandrine Lécart,Nathalie Lecointe,Arun Subramaniam,Sefik S. Alkan,Donghui Ni,Rong Chen,Vera Boulay,Jérôme Pène,Kenji Kuroiwa,Shin-ichi Tominaga,Hans Yssel +10 more
TL;DR: The results show that the T1/ST2 gene products are inducible proteins and that human Th2 cells, in addition to expressing ST2L at their cell surface, secrete ST2 following activation.