Vera Kovaleva

TL;DR: In this article, the authors discuss ER stress as a therapeutic target to treat Parkinson's disease and summarize the existing preclinical data on the regulation of ER stress for PD treatment; they point out the crucial aspects for successful clinical translation of UPR-regulating GFs and new prospective in GFs-based treatments of PD, focusing on ER stress regulation.

TL;DR: In this paper , the binding interface between MANF and IRE1α was identified, and the expression of wild-type MANF, but not its IRE 1α binding-deficient mutant, attenuates UPR signaling by decreasing IREα oligomerization; phosphorylation; splicing of Xbp1, Atf6, and Txnip levels; and protecting neurons from ER stress-induced death.

TL;DR: In this paper, the transmembrane domain of TRKB, a BDNF receptor promoting neuronal plasticity and antidepressant responses, has a cholesterol-interaction site that may mediate the synaptic effects of cholesterol.

TL;DR: In this article, a target-tailored development and biological characterization of small-molecule inhibitors of fat mass and obesity-associated protein (FTO), an RNA N6-methyladenosine (m6A) demethylase, is presented.

TL;DR: It is suggested that binding to and facilitation of BDNF signaling through TRKB is the common mechanism for antidepressant action, which proposes a framework for how molecular effects of antidepressants are translated into clinical mood recovery.