F
Frederike Winkel
Researcher at University of Helsinki
Publications - 15
Citations - 407
Frederike Winkel is an academic researcher from University of Helsinki. The author has contributed to research in topics: Tropomyosin receptor kinase B & Perineuronal net. The author has an hindex of 5, co-authored 13 publications receiving 173 citations.
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Journal ArticleDOI
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Plinio C. Casarotto,Mykhailo Girych,Senem Merve Fred,Vera Kovaleva,Rafael Moliner,Giray Enkavi,Caroline Biojone,Cecilia Cannarozzo,Madhusmita Pryiadrashini Sahu,Katja Kaurinkoski,Cecilia A. Brunello,Anna Steinzeig,Frederike Winkel,Sudarshan Patil,Stefan Vestring,Tsvetan Serchov,Cassiano R.A.F. Diniz,Cassiano R.A.F. Diniz,Liina Laukkanen,Iseline Cardon,Iseline Cardon,Iseline Cardon,Hanna Antila,Hanna Antila,Tomasz Róg,Timo Petteri Piepponen,Clive R. Bramham,Claus Normann,Sari E. Lauri,Mart Saarma,Ilpo Vattulainen,Eero Castrén +31 more
TL;DR: In this paper, the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepressant responses, has a cholesterol-sensing function that mediates synaptic effects of cholesterol.
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iPlasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants.
TL;DR: It is proposed that iPlasticity might be a critical component of AD action, and it is demonstrated that i Plasticity occurs in the visual cortex, fear erasure network, extinction of aggression caused by social isolation, and spatial reversal memory in rodent models.
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Distinct effects of perinatal exposure to fluoxetine or methylmercury on parvalbumin and perineuronal nets, the markers of critical periods in brain development.
TL;DR: It is suggested that perinatal fluoxetine and methylmercury might delay the closure and the onset, respectively, of the critical periods in the amygdala and hippocampus.
Journal ArticleDOI
Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons.
Angelina Lesnikova,Plinio C. Casarotto,Senem Merve Fred,Mikko Voipio,Frederike Winkel,Anna Steinzeig,Hanna Antila,Juzoh Umemori,Caroline Biojone,Eero Castrén +9 more
TL;DR: It is proposed that both chABC and fluoxetine reopen critical period-like plasticity in the adult visual cortex by promoting TRKB signaling in PV+ neurons through inhibition of TRKB dephosphorylation by the PTPσ-CSPG complex.
Journal ArticleDOI
Pharmacological and optical activation of TrkB in Parvalbumin interneurons regulate intrinsic states to orchestrate cortical plasticity.
Frederike Winkel,Maria Ryazantseva,Mathias Benjamin Voigt,Giuliano Didio,Antonia Lilja,Maria Llach Pou,Anna Steinzeig,Juliana Harkki,Jonas Englund,Stanislav Khirug,Claudio Rivera,Satu Palva,Tomi Taira,Sari E. Lauri,Juzoh Umemori,Eero Castrén +15 more
TL;DR: This paper showed that Parvalbumin-positive interneurons regulate the closure of developmental critical periods and can alternate between high and low plasticity states in response to experience in adulthood.