C
Cassiano R.A.F. Diniz
Researcher at University of São Paulo
Publications - 24
Citations - 464
Cassiano R.A.F. Diniz is an academic researcher from University of São Paulo. The author has contributed to research in topics: Tropomyosin receptor kinase B & Medicine. The author has an hindex of 7, co-authored 18 publications receiving 230 citations. Previous affiliations of Cassiano R.A.F. Diniz include University of Helsinki.
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Journal ArticleDOI
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Plinio C. Casarotto,Mykhailo Girych,Senem Merve Fred,Vera Kovaleva,Rafael Moliner,Giray Enkavi,Caroline Biojone,Cecilia Cannarozzo,Madhusmita Pryiadrashini Sahu,Katja Kaurinkoski,Cecilia A. Brunello,Anna Steinzeig,Frederike Winkel,Sudarshan Patil,Stefan Vestring,Tsvetan Serchov,Cassiano R.A.F. Diniz,Cassiano R.A.F. Diniz,Liina Laukkanen,Iseline Cardon,Iseline Cardon,Iseline Cardon,Hanna Antila,Hanna Antila,Tomasz Róg,Timo Petteri Piepponen,Clive R. Bramham,Claus Normann,Sari E. Lauri,Mart Saarma,Ilpo Vattulainen,Eero Castrén +31 more
TL;DR: In this paper, the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepressant responses, has a cholesterol-sensing function that mediates synaptic effects of cholesterol.
Journal ArticleDOI
Neuronal NOS Inhibitor and Conventional Antidepressant Drugs Attenuate Stress-induced Fos Expression in Overlapping Brain Regions
Michelle Silva,Daniele C. Aguiar,Cassiano R.A.F. Diniz,Francisco Silveira Guimarães,Sâmia R.L. Joca +4 more
TL;DR: Results show that 7-NI produces similar behavioral and neuronal activation effects to those of typical antidepressants, suggesting that these drugs share common neurobiological substrates.
Journal ArticleDOI
Beyond good and evil: A putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment.
TL;DR: The resulting hypothesis suggests that both BD NF/proBDNF and BDNF/propeptide act as protagonists to fine-tune antidepressant-dependent neuroplasticity in crucial brain structures to modulate behavioral responses to stress.
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Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN
Cassiano R.A.F. Diniz,Plinio C. Casarotto,Senem Merve Fred,Caroline Biojone,Eero Castrén,Sâmia R.L. Joca +5 more
TL;DR: Losartan exerts antidepressant‐like effect by an angiotensin receptor type‐2 (AGTR2)‐dependent mechanism and the blockade of AGTR1 has therapeutic potential as a novel antidepressant therapy.
Journal ArticleDOI
NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress.
TL;DR: The results suggest that the glutamatergic-NO system of the DH and VH are both able to modulate behavioral responses in the FST, albeit with differential participation along time after stress exposure.