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Caroline Biojone
Researcher at University of Helsinki
Publications - 52
Citations - 1288
Caroline Biojone is an academic researcher from University of Helsinki. The author has contributed to research in topics: Tropomyosin receptor kinase B & Hippocampus. The author has an hindex of 15, co-authored 46 publications receiving 893 citations. Previous affiliations of Caroline Biojone include University of São Paulo.
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Journal ArticleDOI
Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors
T. V. Zanelati,Caroline Biojone,Fabrício A. Moreira,Francisco Silveira Guimarães,Sâmia R.L. Joca +4 more
TL;DR: The hypothesis that CBD would have antidepressant‐like activity in mice as assessed by the forced swimming test was tested and it was investigated if these responses depended on the activation of 5‐HT1A receptors and on hippocampal expression of brain‐derived neurotrophic factor (BDNF).
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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Plinio C. Casarotto,Mykhailo Girych,Senem Merve Fred,Vera Kovaleva,Rafael Moliner,Giray Enkavi,Caroline Biojone,Cecilia Cannarozzo,Madhusmita Pryiadrashini Sahu,Katja Kaurinkoski,Cecilia A. Brunello,Anna Steinzeig,Frederike Winkel,Sudarshan Patil,Stefan Vestring,Tsvetan Serchov,Cassiano R.A.F. Diniz,Cassiano R.A.F. Diniz,Liina Laukkanen,Iseline Cardon,Iseline Cardon,Iseline Cardon,Hanna Antila,Hanna Antila,Tomasz Róg,Timo Petteri Piepponen,Clive R. Bramham,Claus Normann,Sari E. Lauri,Mart Saarma,Ilpo Vattulainen,Eero Castrén +31 more
TL;DR: In this paper, the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepressant responses, has a cholesterol-sensing function that mediates synaptic effects of cholesterol.
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Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors
Amanda J. Sales,Caroline Biojone,Mateus S. Terceti,Francisco Silveira Guimarães,Marcus Vinicius de Matos Gomes,Samia R. L. Joca +5 more
TL;DR: The effects induced by systemic or intra‐hippocampal administration of inhibitors of DNA methyltransferase (DNMT) in rats submitted to a range of behavioural tests are investigated.
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Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence.
Karina Montezuma,Caroline Biojone,S.F. Lisboa,Fernando Q. Cunha,Francisco Silveira Guimarães,Sâmia R.L. Joca +5 more
TL;DR: The results are the first to show that selective inhibition of iNOS or its knockdown induces antidepressant-like effects, therefore suggesting that iN OS-mediated NO synthesis is involved in the modulation of stress-induced behavioral consequences, and further support NO involvement in the neurobiology of depression.
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Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.
Carlos P. Fitzsimons,Emma J. van Bodegraven,Marijn Schouten,Roy Lardenoije,Konstantinos Kompotis,Gunter Kenis,Mark van den Hurk,Marco P. Boks,Caroline Biojone,Samia R. L. Joca,Harry W.M. Steinbusch,Katie Lunnon,Diego Mastroeni,Jonathan Mill,Paul J. Lucassen,Paul D. Coleman,Daniel L.A. van den Hove,Bart P. F. Rutten,Bart P. F. Rutten +18 more
TL;DR: The epigenetic mechanisms relevant for NSCs and AD etiology are reviewed, and the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, are reviewed.