Showing papers by "Véronique Giudicelli published in 2010"

Standardized Sequence and Structure Analysis of Antibody Using IMGT

Abstract: IMGT, the international ImMunoGeneTics information system (http://www. imgt.org) (Lefranc et al. 2009), was created in 1989 at Montpellier, France (CNRS and Universite Montpellier 2), to standardize the immunogenetics data and to manage the huge diversity of the antigen receptors, immunoglobulins (IG) or antibodies and T cell receptors (TR) (Lefranc and Lefranc 2001a, b). IMGT is the international reference in immunogenetics and immunoinformatics, and its standards have been approved by the World Health Organization–International Union of Immunological Societies (WHO–IUIS) Nomenclature Committee (Lefranc 2007, 2008). It provides a common access to standardized and integrated data from genome, proteome, genetics and three-dimensional (3D) structures (Lefranc et al. 2005a). IMGT comprises six databases (for sequences, genes and 3D structures), 15 online tools and Web resources (more than 10,000 HTML pages) (Lefranc et al. 2009) (Fig. 2.1). The accuracy and the consistency of the IMGT data are based on IMGT-ONTOLOGY, the first ontology for immunogenetics and immunoinformatics (Giudicelli and Lefranc 1999; Lefranc et al. 2004; Duroux et al. 2008). IMGT provides the informatics frame and knowledge environment for a standardized analysis of the antibody sequences and 3D structures, in the context of antibody engineering (single chain Fragment variable (scFv), phage displays, combinatorial libraries) and antibody humanization (chimeric, humanized and human antibodies).