J
Jesper Jurlander
Researcher at University of Copenhagen
Publications - 44
Citations - 2198
Jesper Jurlander is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Chronic lymphocytic leukemia & Population. The author has an hindex of 22, co-authored 44 publications receiving 2098 citations. Previous affiliations of Jesper Jurlander include Uppsala University.
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Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
Andreas Agathangelidis,Nikos Darzentas,Anastasia Hadzidimitriou,Xavier Brochet,Fiona Murray,Xiao-Jie Yan,Zadie Davis,Ellen J. van Gastel-Mol,Cristina Tresoldi,Charles C. Chu,Nicola Cahill,Véronique Giudicelli,Boris Tichy,Lone Bredo Pedersen,Letizia Foroni,Lisa Bonello,Agnieszka Janus,Karin E. Smedby,Achilles Anagnostopoulos,Hélène Merle-Béral,Nikolaos Laoutaris,Gunnar Juliusson,Paola Francia di Celle,Šárka Pospíšilová,Jesper Jurlander,Christian H. Geisler,Athanasios Tsaftaris,Marie-Paule Lefranc,Anton W. Langerak,David Oscier,Nicholas Chiorazzi,Chrysoula Belessi,Frederic Davi,Richard Rosenquist,Paolo Ghia,Kostas Stamatopoulos +35 more
TL;DR: It is documented that CLL may be subdivided into 2 distinct categories: one with stereotyped and the other with nonstereotyped BCRs, at an approximate ratio of 1:2, and evidence suggests a different ontogeny for these 2 categories.
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Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk
Dalemari Crowther-Swanepoel,Peter Broderick,Maria Chiara Di Bernardo,Sara E. Dobbins,María Dolores Torres,Mahmoud Mansouri,Clara Ruiz-Ponte,Anna Enjuanes,Richard Rosenquist,Angel Carracedo,Jesper Jurlander,Elias Campo,Gunnar Juliusson,Emilio Montserrat,Karin E. Smedby,Martin J. S. Dyer,Estella Matutes,Claire Dearden,Nicola J. Sunter,Andrew G. Hall,Tryfonia Mainou-Fowler,Graham Jackson,Geoffrey Summerfield,Robert J. Harris,Andrew R. Pettitt,David Allsup,James R. Bailey,Guy Pratt,Chris Pepper,Christopher Fegan,Anton Parker,David Oscier,James M. Allan,Daniel Catovsky,Richard S. Houlston +34 more
TL;DR: The genome-wide association study of 299,983 tagging SNPs with validation in four additional series totaling 2,503 cases and 5,789 controls provides further evidence for genetic susceptibility to this B-cell hematological malignancy.
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The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein–kinase–dependent mechanism
TL;DR: It is demonstrated that cross-linking of rituximab bound to CD20 on freshly isolated B-CLL cells induces apoptosis through a signaling pathway that is dependent on p38 MAP-kinase activation.
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The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow.
TL;DR: A highly individualized expression of the transcription factors, which can form the basis for the heterogeneous expression of granule proteins during granulopoiesis and cell cycle arrest in metamyelocytes, is demonstrated.
Journal Article
Screening For Copy-Number Alterations And Loss-Of-Heterozygosity In Chronic Lymphocytic Leukemia - A Comparative Study Of Four Differently Designed, High Resolution Microarray Platforms
Rebeqa Gunnarsson,Johan Staaf,Mattias Jansson,Anne Marie Ottesen,H. Goeransson,Ulrika Liljedahl,Ulrik Ralfkiaer,Mahmoud Mansouri,Anne Mette Buhl,K. Ekstrom Smedby,Henrik Hjalgrim,A. C. Syvaenen,Åke Borg,Anders Isaksson,Jesper Jurlander,Gunnar Juliusson,Richard Rosenquist +16 more
TL;DR: Cross‐platform comparison revealed 29 concordantly detected CNAs, including known recurrent alterations, which confirmed that all platforms are powerful tools when screening for large aberrations, but detection of 32 additional regions present in 2–3 platforms illustrated a discrepancy in detection of small CNAs.