K
Kostas Stamatopoulos
Researcher at Science for Life Laboratory
Publications - 318
Citations - 10721
Kostas Stamatopoulos is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Chronic lymphocytic leukemia & IGHV@. The author has an hindex of 48, co-authored 271 publications receiving 9042 citations. Previous affiliations of Kostas Stamatopoulos include Uppsala University & Aristotle University of Thessaloniki.
Papers
More filters
Journal ArticleDOI
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Sílvia Beà,Rafael Valdés-Mas,Neus Villamor,Jesús Gutiérrez-Abril,José I. Martín-Subero,Marta Munar,Carlota Rubio-Perez,Pedro Jares,Marta Aymerich,Tycho Baumann,Renée Beekman,Laura Belver,Anna Carrió,Giancarlo Castellano,Guillem Clot,Enrique Colado,Dolors Colomer,Dolors Costa,Julio Delgado,Anna Enjuanes,Xavier Estivill,Adolfo A. Ferrando,Josep Lluís Gelpí,Blanca Gonzalez,Santiago Gonzalez,Marcos González,Marta Gut,Jesús M. Hernández-Rivas,Mónica López-Guerra,David Martín-García,Alba Navarro,Pilar Nicolás,Modesto Orozco,Angel Ramirez Payer,Magda Pinyol,David G. Pisano,Diana A. Puente,Ana C. Queirós,Víctor Quesada,Carlos M. Romeo-Casabona,Cristina Royo,Romina Royo,María Rozman,Nuria Russiñol,Itziar Salaverria,Kostas Stamatopoulos,Hendrik G. Stunnenberg,David Tamborero,María José Terol,Alfonso Valencia,Nuria Lopez-Bigas,David Torrents,Ivo Gut,Armando López-Guillermo,Carlos López-Otín,Elias Campo +56 more
TL;DR: An integrated portrait of the CLL genomic landscape is provided, new recurrent driver mutations of the disease are identified, and clinical interventions that may improve the management of this neoplasia are suggested.
Journal ArticleDOI
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
Kostas Stamatopoulos,Chrysoula Belessi,Carol Moreno,Myriam Boudjograh,Giuseppe Guida,Tatjana Smilevska,Lynda Belhoul,Stefania Stella,Niki Stavroyianni,Marta Crespo,Anastasia Hadzidimitriou,Laurent Sutton,Francesc Bosch,Nikolaos Laoutaris,Achilles Anagnostopoulos,Emili Montserrat,Athanasios Fassas,Guillaume Dighiero,Federico Caligaris-Cappio,Hélène Merle-Béral,Paolo Ghia,Frederic Davi +21 more
TL;DR: It is suggested that a particular antigen-binding site can be critical in determining the clinical features and outcome for at least some CLL patients.
Journal ArticleDOI
Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways.
Magdalena A. Berkowska,Gertjan J. Driessen,Vasilis Bikos,Christina Grosserichter-Wagener,Kostas Stamatopoulos,Andrea Cerutti,Bing He,Katharina Biermann,Johan F. Lange,Mirjam van der Burg,Jacques J.M. van Dongen,Menno C. van Zelm +11 more
TL;DR: Light is shed on human germinal center-dependent and -independent B-cell memory formation and new opportunities to study these processes in immunologic diseases are provided.
Journal ArticleDOI
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
Andreas Agathangelidis,Nikos Darzentas,Anastasia Hadzidimitriou,Xavier Brochet,Fiona Murray,Xiao-Jie Yan,Zadie Davis,Ellen J. van Gastel-Mol,Cristina Tresoldi,Charles C. Chu,Nicola Cahill,Véronique Giudicelli,Boris Tichy,Lone Bredo Pedersen,Letizia Foroni,Lisa Bonello,Agnieszka Janus,Karin E. Smedby,Achilles Anagnostopoulos,Hélène Merle-Béral,Nikolaos Laoutaris,Gunnar Juliusson,Paola Francia di Celle,Šárka Pospíšilová,Jesper Jurlander,Christian H. Geisler,Athanasios Tsaftaris,Marie-Paule Lefranc,Anton W. Langerak,David Oscier,Nicholas Chiorazzi,Chrysoula Belessi,Frederic Davi,Richard Rosenquist,Paolo Ghia,Kostas Stamatopoulos +35 more
TL;DR: It is documented that CLL may be subdivided into 2 distinct categories: one with stereotyped and the other with nonstereotyped BCRs, at an approximate ratio of 1:2, and evidence suggests a different ontogeny for these 2 categories.
Journal ArticleDOI
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
Fiona Murray,Nikos Darzentas,Anastasia Hadzidimitriou,Gerard Tobin,Myriarn Boudjogra,Cristina Scielzo,Nikolaos Laoutaris,Karin Karlsson,Fanny Baran-Marzsak,Athanasios Tsaftaris,Carol Moreno,Achilles Anagnostopoulos,Federico Caligaris-Cappio,Dominique Vaur,Christos A. Ouzounis,Chrysoula Belessi,Paolo Ghia,Fred Davi,Richard Rosenquist,Kostas Stamatopoulos +19 more
TL;DR: The precise targeting and distinctive features of somatic hypermutation in selected subgroups of CLL patients provide further evidence for selection by specific antigenic element(s).