Vi T. Tang

TL;DR: A novel approach that combines proximity-dependent biotinylation and proteomics together with genome-scale CRISPR screening to identify SURf4, a homologue of the yeast cargo receptor Erv29p, as a primary mediator of PCSK9 secretion in HEK293T cells supports a model in which SURF4 functions as an ER cargo receptor mediating the efficient cellular secretion of PC SK9.

TL;DR: Human HCM demonstrates calcium mishandling through both genotype-specific and common pathways, whereas sarcoplasmic endoplasmIC reticular calcium ATPase 2 abundance and sarcoplasmsic reticulum Ca uptake are depressed in both sarcomere mutation–positive and –negative HCM.

TL;DR: Cardiomyocytes have an innate capacity to attain normal MyBP-C stoichiometry despite MYBPC3 allelic loss of function due to truncating mutations, indicating protein-level compensation through a previously uncharacterized mechanism.

TL;DR: In an unbiased coimmunoprecipitation/mass spectrometry screen, HSP70-family chaperones were identified as interactors of both WT and mutant MYBPC3, and it is suggested that the HSC70 chaperone system plays a major role in regulating MYB PC3 protein turnover.

TL;DR: This work demonstrates that SURF4 functions as an ER cargo receptor that mediates the efficient secretion of EPO, suggesting a new strategy for more efficient production of recombinant EPO.