Greggory Myers

TL;DR: It is indicated that RN-1 can effectively induce HbF levels in red blood cells and reduce disease pathology in SCD mice, and may therefore offer new therapeutic possibilities for treating SCD.

TL;DR: This work defines a new mechanism of GATA2 activity and uncovers miR-126 as a novel regulator of mammalian lymphatic vascular development.

TL;DR: This work demonstrates that SURF4 functions as an ER cargo receptor that mediates the efficient secretion of EPO, suggesting a new strategy for more efficient production of recombinant EPO.

TL;DR: It is found that nuclear receptor corepressor-1 (NCoR1) is a critical component of DRED that acts as a scaffold to unite the DNA-binding and epigenetic enzyme components that elicit DRED function.

TL;DR: This work performed ATAC-seq at four distinct stages of development in mouse thymus, probing the chromatin accessibility landscape in double negative (DN), double positive (DP), CD4 single positive (SP4) and CD8 SP (SP8) thymocytes, and infer stage-specific occupied TF binding sites within known and potentially novel regulatory elements.