V
Victoria A. Bjerregaard
Researcher at Copenhagen University Hospital
Publications - 10
Citations - 630
Victoria A. Bjerregaard is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Chromosomal fragile site & DNA repair. The author has an hindex of 7, co-authored 9 publications receiving 485 citations. Previous affiliations of Victoria A. Bjerregaard include University of Copenhagen.
Papers
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Journal ArticleDOI
Replication stress activates DNA repair synthesis in mitosis
Sheroy Minocherhomji,Songmin Ying,Victoria A. Bjerregaard,Sara Bursomanno,Aiste Aleliunaite,Wei Wu,Hocine W. Mankouri,Huahao Shen,Ying Liu,Ian D. Hickson +9 more
TL;DR: It is suggested that targeting this POLD3-dependent mitotic DNA synthesis is enhanced in aneuploid cancer cells that exhibit intrinsically high levels of chromosomal instability (CIN+) and replicative stress, and could represent a new therapeutic approach.
Journal ArticleDOI
PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis
Christian F. Nielsen,Diana Huttner,Diana Huttner,Anna H. Bizard,Seiki Hirano,Tian-Neng Li,Timea Palmai-Pallag,Victoria A. Bjerregaard,Ying Liu,Erich A. Nigg,Lily Hui-Ching Wang,Lily Hui-Ching Wang,Ian D. Hickson,Ian D. Hickson +13 more
TL;DR: De deletion of PICH in avian cells causes chromosome structural abnormalities, and hypersensitivity to an inhibitor of Topoisomerase II (Topo II), ICRF-193, and it is proposed that PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis.
Journal ArticleDOI
Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.
Lorenza Garribba,Victoria A. Bjerregaard,Marisa M Gonçalves Dinis,Özgün Özer,Wei Wu,Despoina Sakellariou,Javier Peña-Diaz,Ian D. Hickson,Ying Liu +8 more
TL;DR: It is proposed that break-induced DNA replication is required for the replication of FRAXA under folate stress and defined a cellular function for human SLX1, which provides insights into how folate deprivation drives instability in the human genome.
Journal ArticleDOI
Folate deficiency drives mitotic missegregation of the human FRAXA locus
TL;DR: It is shown that folate stress leads to a dramatic increase in missegregation of FRAXA coupled with the formation of single-stranded DNA bridges in anaphase and micronuclei that contain the F RAXA locus, which generates further instability not only at FRAxA itself but also of chromosome X.
Journal ArticleDOI
Chromothripsis and DNA Repair Disorders.
Lusine Nazaryan-Petersen,Victoria A. Bjerregaard,Finn Cilius Nielsen,Niels Tommerup,Zeynep Tümer +4 more
TL;DR: The present review focuses on the underlying mechanisms of chromothripsis and the involvement of defective DNA repair genes, resulting in chromosome instability and Chromosome instability-like rearrangements.