Vikas Saxena

TL;DR: In this article , the authors show activated Tregs and CD4 effector T cells (Teffs) use PD-1/PD-L1 and CD80/PDL1, respectively, to regulate transendothelial migration across lymphatic endothelial cells (LECs).

TL;DR: Overall, FRC-Lama4 critically contributes to a tolerogenic LN niche by supporting T cell migration, constraining T cell activation and proliferation, and promoting Treg differentiation, and serves as a therapeutic target for immunoengineering.

Abstract: The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival

TL;DR: Developed assay is capable of a rapid (3 hrs) identification of tissue of pig origin in tested samples, cost-effective, user-friendly, and requires minimal training making it a method of choice in remote point-of-care sites.

TL;DR: In this article, G-CSF-induced myeloid-derived suppressor cells (MDSC) use a novel mechanism to suppress T cell responses, which may represent a therapeutic target for alloregulatory MDSCs.