V
Vikki M. Weake
Researcher at Purdue University
Publications - 52
Citations - 1964
Vikki M. Weake is an academic researcher from Purdue University. The author has contributed to research in topics: Histone & Drosophila melanogaster. The author has an hindex of 16, co-authored 46 publications receiving 1667 citations. Previous affiliations of Vikki M. Weake include University College West & South University.
Papers
More filters
Journal ArticleDOI
Histone ubiquitination: triggering gene activity.
Vikki M. Weake,Jerry L. Workman +1 more
TL;DR: New evidence is discussed that links histone ubiquitination to other chromatin modifications, which has provided a model for the role of H2B ubiquitinations, in particular, in transcription initiation and elongation.
Journal ArticleDOI
Inducible gene expression: diverse regulatory mechanisms
Vikki M. Weake,Jerry L. Workman +1 more
TL;DR: Events that occur during the transcription cycle in eukaryotes that are important for the rapid and specific activation of gene expression in response to external stimuli are discussed.
Journal ArticleDOI
SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system
Vikki M. Weake,Kenneth K. Lee,Sebastián Guelman,Chia-Hui Lin,Christopher Seidel,Susan M. Abmayr,Jerry L. Workman +6 more
TL;DR: It is established that Nonstop actually functions as an ubiquitin protease to control the levels of ubiquitinated histone H2B in flies, and is the functional homolog of yeast Ubp8, and can substitute for Ub p8 function in yeast cells.
Journal ArticleDOI
Transcriptional Signatures of Aging
Rachel Stegeman,Vikki M. Weake +1 more
TL;DR: The discovery that splicing is misregulated with age suggests that other aspects of gene expression, such as transcription elongation, termination, and polyadenylation, must also be considered as potential mechanisms for age-related changes in transcript levels.
Journal ArticleDOI
Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation
Vikki M. Weake,Jamie O. Dyer,Christopher Seidel,Andrew C. Box,Selene K. Swanson,Allison Peak,Laurence Florens,Michael P. Washburn,Susan M. Abmayr,Jerry L. Workman +9 more
TL;DR: Analysis of the composition, interacting proteins, and genomic distribution of SAGA in muscle and neuronal tissue of late stage Drosophila melanogaster embryos indicates that in metazoans S AGA plays a prominent post-transcription initiation role in tissue-specific gene expression.