Selene K. Swanson

TL;DR: Data indicate that Pol II-associated Set2 methylates H3 providing a transcriptional memory which signals for deacetylation of ORFs by Rpd3S, which erases transcription elongation-associated acetylation to suppress intragenic transcription initiation.

TL;DR: These findings show that macrophages are defended from HIV-1 infection by a mechanism that prevents an unwanted interferon response triggered by self nucleic acids, and uncover an intricate relationship between innate immune mechanisms that control response to self and to retroviral pathogens.

TL;DR: It is demonstrated that the Drosophila Tip60 (dTip60) chromatin-remodeling complex acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av, revealing a previously unknown mechanism for selective histone exchange that uses the concerted action of two distinct Chromatin-Remodeling enzymes within the same multiprotein complex.

TL;DR: It is demonstrated that histone H2B monoubiquitination controls the binding of Cps35 with COMPASS complex, and the addition of exogenous purified Cps 35 to COMPASS purified from a Deltarad6 background results in the generation of a methylation competent COMPASS.

TL;DR: An evolutionarily conserved multisubunit protein complex that contains p130 and E2F4, but not pRB, and mediates the repression of cell cycle-dependent genes in quiescence is revealed.