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Vincent Géli

Researcher at Aix-Marseille University

Publications -  107
Citations -  5304

Vincent Géli is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Telomere & Colicin. The author has an hindex of 41, co-authored 99 publications receiving 4839 citations. Previous affiliations of Vincent Géli include Centre national de la recherche scientifique & University of Basel.

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How telomeres are replicated.

TL;DR: Overall, it emerges that telomere replication relies on a strong synergy between the conventional replication machinery, telomeres protection systems, DNA-damage-response pathways and chromosomal organization.
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Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites

TL;DR: It is demonstrated that H3K4me3 is a prominent and preexisting mark of active meiotic recombination initiation sites, and is already established in vegetative cells, being higher in DSB‐prone regions than in regions with no or little DSB.
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The COMPASS Subunit Spp1 Links Histone Methylation to Initiation of Meiotic Recombination

TL;DR: It is shown that the tethering of a PHD-containing protein, Spp1 (a component of the COMPASS complex), to recombinationally cold regions is sufficient to induce DSB formation, and that Spp 1 physically interacts with Mer2, a key protein of the differentiated chromosomal axis required for D SB formation.
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The DNA damage response at eroded telomeres and tethering to the nuclear pore complex.

TL;DR: By single cell analysis, it is shown that in the absence of telomerase, a single short telomere is sufficient to induce the recruitment of checkpoint and recombination proteins and the existence of collapsed replication forks at eroded telomeres is suggested.