Mary Beth Neilly

TL;DR: It is shown that FTO, as an m6A demethylase, plays a critical oncogenic role in acute myeloid leukemia (AML) and provides profound insights into leukemogenesis and drug response.

TL;DR: It is shown that expression signatures of as few as two miRNAs could accurately discriminate ALL from AML, and that epigenetic regulation might play an important role in the regulation of expression of miRNAAs in acute leukemias.

TL;DR: It is demonstrated that specific alterations in miRNA expression distinguish AMLs with common translocations and imply that the deregulation of specific miRNAs may play a role in the development of leukemia with these associated genetic rearrangements.

TL;DR: In contrast to the frequent down-regulation (or loss-of-function mutations) and critical tumor-suppressor roles of the three TET genes observed in various types of cancers, here it is shown that TET1 is a direct target of MLL-fusion proteins and is significantly up-regulated in M LL-rearranged leukemia, leading to a global increase of 5-hydroxymethylcytosine level.

TL;DR: It is shown that MLL fusion proteins negatively regulate production of miR-150, an miRNA widely repressed in acute leukemia, by blocking mi R-150 precursors from being processed to mature miRNAs through MYC/LIN28 functional axis.