J
Joon-Lin Chew
Researcher at National University of Singapore
Publications - Â 5
Citations - Â 3685
Joon-Lin Chew is an academic researcher from National University of Singapore. The author has contributed to research in topics: Chromatin immunoprecipitation & Transcription factor. The author has an hindex of 5, co-authored 5 publications receiving 3443 citations. Previous affiliations of Joon-Lin Chew include Genome Institute of Singapore.
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Journal ArticleDOI
A global map of p53 transcription-factor binding sites in the human genome.
Chia-Lin Wei,Qiang Wu,Vinsensius B. Vega,Kuo Ping Chiu,Patrick Ng,Tao Zhang,Atif Shahab,How Choong Yong,Yutao Fu,Zhiping Weng,Jianjun Liu,Xiao Dong Zhao,Joon-Lin Chew,Joon-Lin Chew,Yen Ling Lee,Vladimir A. Kuznetsov,Wing-Kin Sung,Lance D. Miller,Bing Lim,Bing Lim,Edison T. Liu,Qiang Yu,Huck-Hui Ng,Huck-Hui Ng,Yijun Ruan +24 more
TL;DR: A robust approach is described that couples chromatin immunoprecipitation (ChIP) with the paired-end ditag (PET) sequencing strategy for unbiased and precise global localization of transcription-factor binding sites (TFBS).
Journal ArticleDOI
Transcriptional regulation of nanog by OCT4 and SOX2.
David Rodda,Joon-Lin Chew,Joon-Lin Chew,Leng-Hiong Lim,Yuin-Han Loh,Yuin-Han Loh,Bei Wang,Huck-Hui Ng,Huck-Hui Ng,Paul Robson +9 more
TL;DR: By specific knockdown of Oct4 and Sox2 mRNA by RNA interference in embryonic stem cells, this work provides genetic evidence for a link between Oct4, Sox2, and the Nanog promoter, extending the understanding of the pluripotent genetic regulatory network within which the Sox2-Oct4 complex are at the top of the regulatory hierarchy.
Journal ArticleDOI
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
Joon-Lin Chew,Yuin-Han Loh,Yuin-Han Loh,Wensheng Zhang,Xi Chen,Xi Chen,Wai Leong Tam,Leng-Siew Yeap,Pin Li,Yen-Sin Ang,Bing Lim,Bing Lim,Paul Robson,Paul Robson,Huck-Hui Ng,Huck-Hui Ng +15 more
TL;DR: A positive and potentially self-reinforcing regulatory loop that maintains Pou5f1 and Sox2 expression via the Oct4/Sox2 complex in pluripotent cells is uncovered.
Journal ArticleDOI
Evolution of the mammalian transcription factor binding repertoire via transposable elements
Guillaume Bourque,Bernard Leong,Vinsensius B. Vega,Xi Chen,Yen Ling Lee,Kandhadayar G. Srinivasan,Joon-Lin Chew,Yijun Ruan,Chia-Lin Wei,Huck-Hui Ng,Edison T. Liu +10 more
TL;DR: It is established that these repeat-associated binding sites (RABS) have been associated with significant regulatory expansions throughout the mammalian phylogeny and that transposable elements play an important role in expanding the repertoire of binding sites.
Journal ArticleDOI
p53-regulated Transcriptional Program Associated with Genotoxic Stress-induced Apoptosis
Patricia S. Kho,Zhen Wang,Li Zhuang,Yuqing Li,Joon-Lin Chew,Joon-Lin Chew,Huck-Hui Ng,Huck-Hui Ng,Edison T. Liu,Qiang Yu +9 more
TL;DR: The transcriptional response of HCT116 colorectal cancer cells during apoptosis induced by the anticancer drug 5-fluorouracil is assessed as the function of p53 status, and 230 potential targets that are regulated by p53 are identified.