Y
Yuriy L. Orlov
Researcher at I.M. Sechenov First Moscow State Medical University
Publications - 118
Citations - 9376
Yuriy L. Orlov is an academic researcher from I.M. Sechenov First Moscow State Medical University. The author has contributed to research in topics: Gene & Genomics. The author has an hindex of 24, co-authored 104 publications receiving 8583 citations. Previous affiliations of Yuriy L. Orlov include Agency for Science, Technology and Research & Russian Academy of Sciences.
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Journal ArticleDOI
Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
Xi Chen,Han Xu,Ping Yuan,Fang Fang,Fang Fang,Mikael Huss,Vinsensius B. Vega,Eleanor Wong,Yuriy L. Orlov,Weiwei Zhang,Weiwei Zhang,Jianming Jiang,Jianming Jiang,Yuin-Han Loh,Yuin-Han Loh,Hock Chuan Yeo,Zhen Xuan Yeo,Vipin Narang,Kunde R Govindarajan,Bernard Leong,Atif Shahab,Yijun Ruan,Guillaume Bourque,Wing-Kin Sung,Neil D. Clarke,Chia-Lin Wei,Huck-Hui Ng,Huck-Hui Ng +27 more
TL;DR: This study uses chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing to map the locations of TF-binding sites and identifies important features of the transcriptional regulatory networks that define ES-cell identity.
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An oestrogen-receptor-α-bound human chromatin interactome
Melissa J. Fullwood,Mei Hui Liu,You Fu Pan,Jun Liu,Han Xu,Yusoff Bin Mohamed,Yuriy L. Orlov,Stoyan Velkov,Andrea Ho,Poh Huay Mei,Elaine G.Y. Chew,Phillips Yao Hui Huang,Willem Welboren,Yuyuan Han,Hong Sain Ooi,Pramila N. Ariyaratne,Vinsensius B. Vega,Yanquan Luo,Peck Yean Tan,Pei Ye Choy,K. D. Senali Abayratna Wansa,Bing Zhao,Kar Sian Lim,Shi Chi Leow,Jit Sin Yow,Roy Joseph,Haixia Li,Kartiki V. Desai,Jane S. Thomsen,Yew Kok Lee,R. Krishna Murthy Karuturi,Thoreau Herve,Guillaume Bourque,Hendrik G. Stunnenberg,Xiaoan Ruan,Valere Cacheux-Rataboul,Wing-Kin Sung,Wing-Kin Sung,Edison T. Liu,Chia-Lin Wei,Edwin Cheung,Edwin Cheung,Edwin Cheung,Yijun Ruan,Yijun Ruan +44 more
TL;DR: It is proposed that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes and is described as a new strategy, chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) for the de novo detection of global Chromatin interactions.
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Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation.
Guoliang Li,Xiaoan Ruan,Raymond K. Auerbach,Kuljeet Singh Sandhu,Meizhen Zheng,Ping Wang,Huay Mei Poh,Yufen Goh,Joanne Lim,Jingyao Zhang,Hui Shan Sim,Su Qin Peh,Fabianus Hendriyan Mulawadi,Chin Thing Ong,Yuriy L. Orlov,Shuzhen Hong,Zhizhuo Zhang,Steve Landt,Debasish Raha,Ghia Euskirchen,Chia-Lin Wei,Weihong Ge,Huaien Wang,Carrie A. Davis,Katherine I. Fisher-Aylor,Ali Mortazavi,Mark Gerstein,Thomas R. Gingeras,Barbara J. Wold,Yi Sun,Melissa J. Fullwood,Edwin Cheung,Edwin Cheung,Edison T. Liu,Wing-Kin Sung,Wing-Kin Sung,Michael Snyder,Yijun Ruan,Yijun Ruan +38 more
TL;DR: In conclusion, this study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells through widespread promoter-centered intragenic, extragenics, and intergenic interactions.
Journal ArticleDOI
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells.
Xiao Dong Zhao,Xu Han,Joon Lin Chew,Joon Lin Chew,Jun Liu,Kuo Ping Chiu,Andre Choo,Yuriy L. Orlov,Wing-Kin Sung,Wing-Kin Sung,Atif Shahab,Vladimir A. Kuznetsov,Guillaume Bourque,Steve Oh,Yijun Ruan,Huck-Hui Ng,Huck-Hui Ng,Chia-Lin Wei +17 more
TL;DR: These global histone methylation maps provide an epigenetic framework that enables the discovery of novel transcriptional networks and delineation of different genetic compartments of the pluripotent cell genome.
Journal ArticleDOI
Global mapping of c-Myc binding sites and target gene networks in human B cells
Karen I. Zeller,Xiaodong Zhao,Charlie W.H. Lee,Kuo Ping Chiu,Fei Yao,Jason T. Yustein,Hong Sain Ooi,Yuriy L. Orlov,Atif Shahab,How Choong Yong,Yutao Fu,Zhiping Weng,Vladimir A. Kuznetsov,Wing-Kin Sung,Yijun Ruan,Chi V. Dang,Chia-Lin Wei +16 more
TL;DR: A snapshot of genome-wide, unbiased characterization of direct Myc binding targets in a model of human B lymphoid tumor using ChIP coupled with pair-end ditag sequencing analysis (ChIP-PET) provides a substantial framework for the understanding of mechanisms of Myc-induced tumorigenesis.