Vladimir Brusic

TL;DR: In this paper, the A−E+ transgenic mouse is highly susceptible to human thyroglobulin (hTg)-induced thyroiditis, but strongly tolerant to a challenge by mTg-primed T cells.

TL;DR: This work defines a Data Learning Process (DLP), a formalization aimed at facilitating knowledge discovery in biological databases, which comprises a series of steps for comprehension of biological data within the bioinformatics framework.

TL;DR: FluKB is representation of a new generation of databases that integrates data, analytical tools, and analytical workflows that enable comprehensive analysis and automatic generation of analysis reports.

TL;DR: The results illustrate that the integration of protein interaction networks with the most comprehensive database of gene expression profiles of the immune cells can be used to generate hypotheses into the underlying mechanisms governing the differentiation and the differential functional activity across the immune cell lineage.

TL;DR: It is suggested that pathogens have evolved under the influence of the host immune system so that surface proteins are depleted in potential MHC-binding peptides, and that identification of a protein likely to contain a single immuno-dominant epitope is likely to be a productive strategy for vaccine design.