Vladimir Brusic

TL;DR: A framework that combines computational tools for the study of immune function and vaccine development, named ImmunoGrid is developed, which combines conceptual models of the immune system, models of antigen processing and presentation, system-level models ofTheimmune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines.

TL;DR: In this paper, a computer-based algorithm was used to predict potential HLA-DR3-binding peptides and have tested them in DR3-transgenic mice, and the results demonstrate the utility of using this algorithm with synthetic peptides to help identify pathogenic T cell epitopes on hTg.

TL;DR: The antigenic basis of the effective graft-versus-leukemia (GvL) responses associated with DLI for the treatment of CLL is elucidated by analyzing the specificity of plasma antibody responses developing in two DLI-treated patients who achieved long-term remission without graft-Versus-host disease.

TL;DR: The comparison of proteomics and transcriptomics data, suggests that highly expressed transcripts have high probability of protein expression, however, approximately 10% of expressed proteins could not be matched with the expressed transcripts.

TL;DR: A cDNA amplicon-based pyrosequencing method to capture 94% of the HLA class I open-reading-frame with only two amplicons per sample, and an analogous method for class II HLA genes, with a primary focus on sequencing the DRB loci, are designed.