Wai Kit Chu

TL;DR: This Review discusses how these proteins might suppress genomic rearrangements, and therefore function as 'caretaker' tumour suppressors.

TL;DR: It is reported that the DNA structure-specific nuclease MUS81–EME1 localizes to CFS loci in early mitotic cells, and promotes the cytological appearance of characteristic gaps or breaks observed at CFSs in metaphase chromosomes, indicating that CFS cleavage actually promotes genome stability.

TL;DR: A high throughput screen of a chemical compound library for small molecule inhibitors of the DNA unwinding activity of Bloom's syndrome protein ML216 shows strong selectivity for BLM in cultured cells, and discusses the potential utility of such a BLM-targeting compound as an anticancer agent.

TL;DR: This review summarises current knowledge on methylated DNA and its implications in cancer to explore its potential as an epigenetic biomarker to be translated for clinical application and proposes that the identification of biomarkers with higher accuracy and more effective detection methods will enable improved clinical management of patients and the intervention at early-stage disease.

TL;DR: It is shown that FBH1 catalyzes regression of a model replication fork in vitro and promotes fork regression in vivo in response to replication perturbation, andFBH1-dependent signaling promotes checkpoint control and preserves genome integrity.