Walter Malorni

TL;DR: The European Commission has evidenced the need to combine the knowledge on sex-driven response to nutrients with that on gender-related dietary choices in order to design tailored preventive interventions aimed at effectively promoting healthy lifestyles.

TL;DR: In this review, the critical implications of autophagy in the pathogenesis, progression, and treatment of lymphoproliferative disorders are recapitulate.

TL;DR: Adenosine and 2-chloro-adenosine induce apoptosis of myogenic cells via completely different metabolic pathways, and are consistent with the hypothesis that adenosine accumulation in dystrophic muscles may represent a novel pathogenetic pathway in muscle diseases.

TL;DR: Exposure of mitogen-stimulated peripheral blood mononuclear cells to ox-LDL markedly reduced specific mRNA transcription and release of cytokines relevant for NK cell activity (such as tumor necrosis factor-alpha, interferon gamma, and interleukin 12), which suggest that the impairment ofNK cell activity by ox- LDL likely reflects the concomitant dysregulation of some essential mechanisms of NK cell function.

TL;DR: It is concluded that anti-D4GDI autoantibodies could be capable of triggering important responses in T cells such as cytoskeleton remodeling and autophagy pathway and that, in SLE patients, the chronic exposure to these specific autoantibia could lead to the selection of Autophagy-resistant T cell clones contributing to the pathogenesis of the disease.