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Walter Malorni
Researcher at Istituto Superiore di Sanità
Publications - 371
Citations - 39681
Walter Malorni is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 69, co-authored 363 publications receiving 33990 citations.
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The microenvironment can shift erythrocytes from a friendly to a harmful behavior: Pathogenetic implications for vascular diseases
TL;DR: In line with recent data from the literature, erythrocytes can be proposed as bioindicators of progression in chronic or acute diseases characterized, as a hallmark, by oxidative alterations.
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Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: Alterations underlying surface bleb formation
TL;DR: Experimental evidence supporting a crucial role of thiol oxidation and elevation of cytoplasmic calcium concentration in bleb formation is provided and demonstrates that cytoskeletal structures and the microfilament system in particular, represent important targets in menadione-induced morphological changes in cultured cells.
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Sex in basic research: concepts in the cardiovascular field.
Renée Ventura-Clapier,Elke Dworatzek,Ute Seeland,Georgios Kararigas,Jean-François Arnal,Sandra Brunelleschi,Thomas C. Carpenter,Jeanette Erdmann,Flavia Franconi,Elisa Giannetta,Marek Glezerman,Susanna M. Hofmann,Claudine Junien,Miyuki Katai,Karolina Kublickiene,Inke R. König,Gregor Majdic,Walter Malorni,Christin Mieth,Virginia M. Miller,Rebecca M. Reynolds,Hiroaki Shimokawa,Cara Tannenbaum,Anna Maria D'Ursi,Vera Regitz-Zagrosek +24 more
TL;DR: This expert review is based on the EUGenMed project developing a roadmap for implementing sex and gender in biomedical and health research, and discusses methodological issues, and analyses strength, weaknesses, opportunities and threats in implementing sex-sensitive aspects into basic research.
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Identification of ‘tissue’ transglutaminase binding proteins in neural cells committed to apoptosis
Lucia Piredda,Maria Grazia Farrace,Mario Lo Bello,Walter Malorni,Gennaro Melino,Raffaele Petruzzelli,Mauro Piacentini,Mauro Piacentini +7 more
TL;DR: It is demonstrated that the GST P1‐1 acts as an efficient acyl donor as well as acceptor tTG substrate both in cells and in vitro.
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Mitochondria hyperpolarization is an early event in oxidized low-density lipoprotein-induced apoptosis in Caco-2 intestinal cells.
Claudio Giovannini,Paola Matarrese,Beatrice Scazzocchio,Massimo Sanchez,Roberta Masella,Walter Malorni +5 more
TL;DR: Results point to mitochondrial hyperpolarization as ‘sensitizing feature’ in apoptotic proneness of Caco‐2 intestinal cells to oxLDL exposure and dietary phenolic antioxidizing compounds exerted a significant protective antiapoptotic activity.