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Wan-Ting Tsai
Researcher at National Institutes of Health
Publications - 8
Citations - 137
Wan-Ting Tsai is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Innate immune system. The author has an hindex of 4, co-authored 6 publications receiving 96 citations. Previous affiliations of Wan-Ting Tsai include National Health Research Institutes.
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Journal ArticleDOI
Hepatic Expression of HCV RNA-Dependent RNA Polymerase Triggers Innate Immune Signaling and Cytokine Production
Guann-Yi Yu,Guann-Yi Yu,Guann-Yi Yu,Guobin He,Chia-Yang Li,Martin Tang,Sergei I. Grivennikov,Wan-Ting Tsai,Ming-Sian Wu,Chih-Wen Hsu,Yu Tsai,Lily Hui-Ching Wang,Michael Karin +12 more
TL;DR: It is shown that transient expression of HCV RNA-dependent RNA polymerase (RdRp), NS5B, in mouse liver and human hepatocytes results in production of small RNA species that activate innate immune signaling and induce cytokine production, including type I interferons (IFN) and IL-6.
Journal ArticleDOI
Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and p62/Sequestosome-1-dependent Mitophagy
Wan-Ting Tsai,Yin-Chiu Lo,Ming-Sian Wu,Chia-Yang Li,Yi-Ping Kuo,Yi-Hui Lai,Yu Tsai,Kai-Chieh Chen,Tsung-Hsien Chuang,Chun-Hsu Yao,Jinq-Chyi Lee,Li-Chung Hsu,John T.A. Hsu,Guann-Yi Yu,Guann-Yi Yu +14 more
TL;DR: It is demonstrated that p62-dependent mitophagy has an immunosuppressive role to innate immune response and might serve as a potential immunomodulatory target for inflammation-associated diseases.
Journal ArticleDOI
Establishment of a mouse model for the complete mosquito-mediated transmission cycle of Zika virus.
Yi-Ping Kuo,Kuen-Nan Tsai,Yin-Chiu Luo,Pei-Jung Chung,Yu-Wen Su,Yu Teng,Ming-Sian Wu,Yu-Feng Lin,Chao-Yang Lai,Tsung-Hsien Chuang,Shih-Syong Dai,Fan-Chen Tseng,Cheng-Han Hsieh,De-Jiun Tsai,Wan-Ting Tsai,Chun-Hong Chen,Chun-Hong Chen,Guann-Yi Yu +17 more
TL;DR: The newly developed mouse and mosquito transmission models for ZIKV infection will be useful for the evaluation of antiviral drugs targeting the virus, vector, and host.
Journal ArticleDOI
Glycosylation and S-palmitoylation regulate SARS-CoV-2 spike protein intracellular trafficking
ChihFeng Tien,Wan-Ting Tsai,Chun Hwa Chen,Hui Ju Chou,Mingzi M. Zhang,Jhe-Jhih Lin,En-Ju Lin,Shih-Syong Dai,Yueh-Hsin Ping,Yi-Ping Kuo,Wei-Hsiang Tsai,Hsin-Wei Chen,Guann-Yi Yu +12 more
TL;DR: Wu et al. as discussed by the authors showed that 611LYQD614 and cysteine-rich motifs in SARS-CoV-2 spike (S) are critical for S protein-mediated membrane fusion and infection.
Journal ArticleDOI
Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma.
Ming-Sian Wu,Chun-Hsiang Wang,Fan-Chen Tseng,Hsuan-Ju Yang,Yin-Chiu Lo,Yi-Ping Kuo,De-Jiun Tsai,Wan-Ting Tsai,Guann-Yi Yu,Guann-Yi Yu +9 more
TL;DR: Serum IL-17F concentrations were significantly elevated in HCV patients with severe fibrosis stages, and the data suggest that IL-18F might be used as a valuable biological marker than IL- 17A during chronic fibrosis progression and HCC development inHCV patients.