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Warren M. Zapol
Researcher at Harvard University
Publications - 423
Citations - 26610
Warren M. Zapol is an academic researcher from Harvard University. The author has contributed to research in topics: Nitric oxide & Pulmonary hypertension. The author has an hindex of 81, co-authored 418 publications receiving 25338 citations. Previous affiliations of Warren M. Zapol include Brigham and Women's Hospital & University of British Columbia.
Papers
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Journal ArticleDOI
Pulmonary and Systemic Vascular Resistances After Cardiopulmonary Bypass: Role of Hemolysis
Emanuele Rezoagli,Fumito Ichinose,Sabrina Strelow,Nathalie Roy,Kenneth Shelton,Rui Matsumine,Liu Chen,Edward A. Bittner,Daniel Bloch,Warren M. Zapol,Lorenzo Berra +10 more
TL;DR: Prolonged CPB was associated with increased plasma hemoglobin and plasma nitric oxide consumption and pulmonary and systemic vascular resistances that after CPB would normalize gradually over time, due to clearance of plasma oxyhemoglobin.
Journal ArticleDOI
Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice.
Bodil Petersen,Kenneth D. Bloch,Fumito Ichinose,Hae-Sook Shin,Misako Shigematsu,Aranya Bagchi,Warren M. Zapol,Judith Hellman +7 more
TL;DR: The data indicate that TLR2 activation impairs HPV and induces deleterious systemic effects in mice and suggest thatTLR2 pathways may be important in sepsis-induced respiratory failure.
Book ChapterDOI
Inhaled Nitric Oxide, Clinical Rationale and Applications
Claes Frostell,Warren M. Zapol +1 more
TL;DR: Experimental observations initiated a new field of research activity: examining the clinical and experimental effects of inhaled NO in states of pulmonary hypertension of varied etiology with or without concomitant hypoxemia.
Journal ArticleDOI
Platelet function in acute respiratory failure
Angelina C. A. Carvalho,Angelina C. A. Carvalho,Deborah A. Quinn,Sandra M. Demarinis,Julie Beitz,Warren M. Zapol +5 more
TL;DR: The results suggest that in vivo platelet activation occurs in ARF, and ARF patients have quantitative and qualitative platelet defects that may contribute to thrombotic and hemorrhagic complications.
Journal ArticleDOI
Combined administration of intravenous dipyridamole and inhaled nitric oxide to assess reversibility of pulmonary arterial hypertension in potential cardiac transplant recipients
TL;DR: Intravenous dipyridamole augments and prolongs the pulmonary vasodilator effects of inhaled NO in CHF patients with severe PH and, when administered in combination with NO inhalation, can identify PH reversibility in potential cardiac transplant recipients in whom a pulmonary vasODilator response to inhalation of NO alone is not observed.