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Warren M. Zapol
Researcher at Harvard University
Publications - 423
Citations - 26610
Warren M. Zapol is an academic researcher from Harvard University. The author has contributed to research in topics: Nitric oxide & Pulmonary hypertension. The author has an hindex of 81, co-authored 418 publications receiving 25338 citations. Previous affiliations of Warren M. Zapol include Brigham and Women's Hospital & University of British Columbia.
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Journal ArticleDOI
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
Tslil Ast,Joshua D. Meisel,Shachin Patra,Hong Wang,Robert M. H. Grange,Sharon H. Kim,Sarah E. Calvo,Lauren L. Orefice,Fumiaki Nagashima,Fumito Ichinose,Warren M. Zapol,Gary Ruvkun,David P. Barondeau,Vamsi K. Mootha +13 more
TL;DR: It is reported that when grown in 1% ambient O2, FXN null yeast, human cells, and nematodes are fully viable and hypoxia is identified as a key environmental variable in the pathogenesis associated with FXN depletion, with important mechanistic and therapeutic implications.
Journal ArticleDOI
An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance.
Anupam Patgiri,Anupam Patgiri,Anupam Patgiri,Owen S. Skinner,Owen S. Skinner,Owen S. Skinner,Yusuke Miyazaki,Grigorij Schleifer,Eizo Marutani,Hardik Shah,Hardik Shah,Hardik Shah,Rohit Sharma,Rohit Sharma,Rohit Sharma,Russell P. Goodman,Tsz-Leung To,Tsz-Leung To,Tsz-Leung To,Xiaoyan Robert Bao,Fumito Ichinose,Warren M. Zapol,Vamsi K. Mootha,Vamsi K. Mootha,Vamsi K. Mootha +24 more
TL;DR: This study lays the groundwork for a class of injectable therapeutic enzymes that alleviates intracellular redox imbalances by directly targeting circulating redox-coupled metabolites, and improves NADH:NAD+ balance in the heart and brain.
Journal ArticleDOI
Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS.
TL;DR: No inhalation before or after L-NAME administration in this acute lung injury model reduced Qva/QT, most likely by increasing cGMP concentration in ventilated lung regions and causing selective pulmonary vasodilation.
Patent
Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
Warren M. Zapol,Kenneth D. Bloch +1 more
TL;DR: In this paper, methods of treating, inhibiting or preventing vascular thrombosis or arterial restenosis in a mammal were discussed, including causing the mammal to inhale a therapeutically-effective concentration of gaseous nitric oxide (NO).
Journal ArticleDOI
Autologous Transfusion of Stored Red Blood Cells Increases Pulmonary Artery Pressure
Lorenzo Berra,Riccardo Pinciroli,Christopher P. Stowell,Lin Wang,Binglan Yu,Bernadette O. Fernandez,Martin Feelisch,Cristina Mietto,Eldad A. Hod,Daniel Chipman,Marielle Scherrer-Crosbie,Kenneth D. Bloch,Warren M. Zapol +12 more
TL;DR: Transfusion of autologous leukoreduced blood stored for 40 days was associated with increased plasma hemoglobin levels and increased pulmonary artery pressure, and breathing nitric oxide prevents the increase of pulmonary artery Pressure produced by transfusing stored blood.