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Warren M. Zapol
Researcher at Harvard University
Publications - 423
Citations - 26610
Warren M. Zapol is an academic researcher from Harvard University. The author has contributed to research in topics: Nitric oxide & Pulmonary hypertension. The author has an hindex of 81, co-authored 418 publications receiving 25338 citations. Previous affiliations of Warren M. Zapol include Brigham and Women's Hospital & University of British Columbia.
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Journal ArticleDOI
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
Rajeev Malhotra,Andreas C. Mauer,Christian L. Lino Cardenas,Xiuqing Guo,Jie Yao,Xiaoling Zhang,Florian Wunderer,Florian Wunderer,Albert V. Smith,Quenna Wong,Sonali Pechlivanis,Shih-Jen Hwang,Judy Wang,Lingyi Lu,Christopher J. Nicholson,Georgia Shelton,Mary D. Buswell,Hanna J. Barnes,Haakon H. Sigurslid,Charles Slocum,Caitlin O. Rourke,David K. Rhee,Aranya Bagchi,Sagar U. Nigwekar,Emmanuel S. Buys,Catherine Y. Campbell,Tamara B. Harris,Matthew J. Budoff,Michael H. Criqui,Jerome I. Rotter,Andrew D. Johnson,Ci Song,Nora Franceschini,Stéphanie Debette,Udo Hoffmann,Hagen Kälsch,Markus M. Nöthen,Sigurdur Sigurdsson,Barry I. Freedman,Donald W. Bowden,Karl-Heinz Jöckel,Susanne Moebus,Raimund Erbel,Mary F. Feitosa,Vilmundur Gudnason,George Thanassoulis,Warren M. Zapol,Mark E. Lindsay,Daniel Bloch,Wendy S. Post,Christopher J. O'Donnell +50 more
TL;DR: This translational genomic study identifies the first genetic risk locus associated with calcification of the abdominal aorta and describes a previously unknown role for HDAC9 in the development of vascular calcification, showing that HDAC 9 promotes an osteogenic vascular smooth muscle cell phenotype, enhancing calcification and reducing contractility.
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Inhaled Agonists of Soluble Guanylate Cyclase Induce Selective Pulmonary Vasodilation
Oleg V. Evgenov,Daniel S. Kohane,Kenneth D. Bloch,Johannes-Peter Stasch,Gian Paolo Volpato,Evangelia Bellas,Natalia V. Evgenov,Emmanuel S. Buys,Mark Jean Gnoth,Amanda R. Graveline,Rong Liu,Dean R. Hess,Robert Langer,Warren M. Zapol +13 more
TL;DR: Inhalation of microparticles containing agonists of s GC may provide an effective novel treatment for patients with pulmonary hypertension, particularly when responsiveness to iNO is impaired by oxidation of sGC.
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Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor.
H S Warren,M. L. Glennon,N Wainwright,Stephen Amato,K M Black,S J Kirsch,G R Riveau,Richard I. Whyte,Warren M. Zapol,T J Novitsky +9 more
TL;DR: LPS preincubated with LALF was less mitogenic for murine splenocytes, was less pyrogenic in the rabbit fever assay, and was less lethal in mice which had been sensitized to LPS with actinomycin D, and induced less fever, neutropenia, and pulmonary hypertension when infused into sheep.
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Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery.
Chong Lei,Lorenzo Berra,Emanuele Rezoagli,Emanuele Rezoagli,Binglan Yu,Hailong Dong,Shiqiang Yu,Lihong Hou,Min Chen,Wensheng Chen,Hongbing Wang,Qijun Zheng,Jie Shen,Zhenxiao Jin,Tao Chen,Rong Zhao,Emily Christie,Venkata S. Sabbisetti,Francesco Nordio,Joseph V. Bonventre,Lize Xiong,Warren M. Zapol +21 more
TL;DR: In patients undergoing multiple valve replacement and prolonged cardiopulmonary bypass, administration of nitric oxide decreased the incidence of acute kidney injury, transition to stage 3 chronic kidney disease, and major adverse kidney events at 30 days, 90 days, and 1 year.
Journal ArticleDOI
Selective Pulmonary Vasodilation Induced by Aerosolized Zaprinast
TL;DR: Aerosolization of a cGMP‐selective phosphodiesterase inhibitor alone or combined with NO may be a useful noninvasive therapeutic method to treat acute or chronic pulmonary hypertension.