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Warren M. Zapol
Researcher at Harvard University
Publications - 423
Citations - 26610
Warren M. Zapol is an academic researcher from Harvard University. The author has contributed to research in topics: Nitric oxide & Pulmonary hypertension. The author has an hindex of 81, co-authored 418 publications receiving 25338 citations. Previous affiliations of Warren M. Zapol include Brigham and Women's Hospital & University of British Columbia.
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Journal ArticleDOI
Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving
Allyson G. Hindle,Kaitlin Allen,Annabelle Batten,Luis A. Hückstädt,Jason Turner-Maier,S. Anne Schulberg,Jeremy A. Johnson,Elinor K. Karlsson,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Daniel P. Costa,Daniel Bloch,Warren M. Zapol,Emmanuel S. Buys +13 more
TL;DR: Results of this study suggest that alterations in the NO-cGMP pathway facilitate the diving response, which is consistent with the priority of cerebral perfusion during diving.
Journal ArticleDOI
Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha
Yasuko Nagasaka,Martin Wepler,Robrecht Thoonen,Patrick Sips,Kaitlin Allen,Jan A. Graw,Vincent Yao,Sara M. Burns,Stefan Muenster,Peter Brouckaert,Keith W. Miller,Ken Solt,Emmanuel S. Buys,Fumito Ichinose,Warren M. Zapol +14 more
TL;DR: Congenital deficiency of GC-1α abolished the ability of sevoflurane anesthesia to increase cGMP levels in the whole brain, and increased the concentration of seVofLurane required to induce LORR, raising the threshold for producing sev ofluranes-induced unconsciousness in mice.
Journal ArticleDOI
Cannulation of the proximal aorta during long-term membrane lung perfusion.
M. Terry McEnany,Warren M. Zapol,Jurgen Seebacher,M. Skoskiewicz,Robert C. Schneider,A. John Erdmann,Michael T. Snider,David J. Kanarek,Anthony G. Peck,J. Gordon Scannell +9 more
TL;DR: Recent experience with 4 patients has demonstrated an advantage in delivery of saturated blood to the root of the aorta during venoarterial (VA) bypass, which resulted in long-term survival in 2 patients with post-traumatic gram-negative pneumonitis and other patients, who had viral pneumonia and post-transfusion respiratory failure.
Journal ArticleDOI
Imaging the ovine heparin-protamine interaction with 111In-protamine.
G. Montalescot,Alan J. Fischman,H W Strauss,Robert A. Wilkinson,M. Ahmad,C. Fitzgibbon,D. W. Robinson,Warren M. Zapol +7 more
TL;DR: The lung specificity of the reaction and interspecies differences suggest that ovine pulmonary intravascular macrophages may be activated by heparin-protamine complexes to release thromboxane and provoke acute pulmonary vasoconstriction.