W
Weifeng Gu
Researcher at University of California, Riverside
Publications - 35
Citations - 5239
Weifeng Gu is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Argonaute & RNA. The author has an hindex of 23, co-authored 34 publications receiving 4484 citations. Previous affiliations of Weifeng Gu include University of California, Berkeley & University of Rochester.
Papers
More filters
Journal ArticleDOI
piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline
Masaki Shirayama,Meetu Seth,Heng-Chi Lee,Weifeng Gu,Takao Ishidate,Darryl Conte,Craig C. Mello +6 more
TL;DR: It is shown that the Piwi Argonaute PRG-1 and its genomically encoded piRNA cofactors initiate permanent silencing, and maintenance depends on chromatin factors and the WAGOArgonaute pathway.
Journal ArticleDOI
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.
Pedro J. Batista,J. Graham Ruby,Julie M. Claycomb,H. Rosaria Chiang,Noah Fahlgren,Kristin D. Kasschau,Daniel A. Chaves,Weifeng Gu,Jessica J. Vasale,Shenghua Duan,Darryl Conte,Shujun Luo,Gary P. Schroth,James C. Carrington,David P. Bartel,Craig C. Mello,Craig C. Mello +16 more
TL;DR: These findings demonstrate that 21U-RNAs are the piRNAs of C. elegans and link this class of small RNAs and their associated Piwi Argonaute to the maintenance of temperature-dependent fertility.
Journal ArticleDOI
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.
Weifeng Gu,Masaki Shirayama,Darryl Conte,Jessica J. Vasale,Pedro J. Batista,Julie M. Claycomb,James J. Moresco,Elaine M. Youngman,Jennifer Keys,Matthew J. Stoltz,Chun-Cheih G. Chen,Daniel A. Chaves,Daniel A. Chaves,Shenghua E. Duan,Krisitin D. Kasschau,Noah Fahlgren,John R. Yates,Shohei Mitani,James C. Carrington,Craig C. Mello,Craig C. Mello +20 more
TL;DR: Deep-sequencing and genetic approaches are combined to explore the biogenesis and function of endo-siRNAs in C. elegans and show that, in the germline, one system is dependent on worm-specific AGOs, including WAGO-1, which localizes to germline nuage structures called P granules.
Journal ArticleDOI
The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation
Julie M. Claycomb,Pedro J. Batista,Ka Ming Pang,Weifeng Gu,Jessica J. Vasale,Josien C. van Wolfswinkel,Josien C. van Wolfswinkel,Daniel A. Chaves,Daniel A. Chaves,Masaki Shirayama,Shohei Mitani,René F. Ketting,Darryl Conte,Craig C. Mello,Craig C. Mello +14 more
TL;DR: These findings support a model in which CSR-1 complexes target protein-coding domains to promote their proper organization within the holocentric chromosomes of C. elegans.
Journal ArticleDOI
Rapid tRNA Decay Can Result from Lack of Nonessential Modifications
Andrei Alexandrov,Irina Chernyakov,Weifeng Gu,Shawna L. Hiley,Timothy P. Hughes,Elizabeth J. Grayhack,Eric M. Phizicky +6 more
TL;DR: It is shown that m7G46 methyltransferase Trm8p/Trm82p acts as a hub of synthetic interactions with several tRNA modification enzymes, resulting in temperature-sensitive growth and defines a rapid tRNA degradation (RTD) pathway that is independent of the TRF4/RRP6-dependent nuclear surveillance pathway.