Weiye Deng

TL;DR: In this article, a cellular-nanoporation method for the production of large quantities of exosomes containing therapeutic mRNAs and targeting peptides was reported, and the exosome-containing exosomal mRNA transcripts were shown to restore tumour-suppressor function, enhanced inhibition of tumour growth and increased survival.

TL;DR: The mechanisms of radiation and immune system interaction are summarized, current challenges in radiation andimmune checkpoint blockade therapy are discussed, and possible future approaches to boost this combination are discussed.

TL;DR: In glioblastoma mouse models, temozolomide improves the phagocytosis effect of CD47 blockade in APCs and results in the activation of adaptive anti-tumour responses, revealing a dynamic relationship between innate and adaptive immune regulation in tumours.

TL;DR: The evidence that supports reciprocal interactions between cancer immunotherapy and radiotherapy is highlighted, where in addition to the traditional notion that radiation serves to enhance the activation of antitumor immunity, an alternative scenario also exists in which T-cell activation by cancer Immunotherapy may sensitize tumors to radiation treatment through mechanisms that include normalization of the tumor vasculature and tissue hypoxia.

TL;DR: Together, these results demonstrate a dose-dependent synergism between anti-angiogenic therapy and immune checkpoint blockade, thus providing important insights into the optimal strategies for combining immunotherapy with molecular-targeted agents.