J
Jose Otero
Researcher at Ohio State University
Publications - 78
Citations - 2327
Jose Otero is an academic researcher from Ohio State University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 65 publications receiving 1692 citations. Previous affiliations of Jose Otero include The Ohio State University Wexner Medical Center & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.
Zhaogang Yang,Zhaogang Yang,Junfeng Shi,Jing Xie,Yifan Wang,Jingyao Sun,Tongzheng Liu,Yarong Zhao,Xiuting Zhao,Xinmei Wang,Yifan Ma,Veysi Malkoc,Chi-Ling Chiang,Weiye Deng,Yuanxin Chen,Yuan Fu,Kwang J. Kwak,Yamin Fan,Chen Kang,Changcheng Yin,June Rhee,Paul Bertani,Jose Otero,Wu Lu,Kyuson Yun,Andrew S. Lee,Wen Jiang,Lesheng Teng,Betty Y.S. Kim,Betty Y.S. Kim,L. James Lee +30 more
TL;DR: In this article, a cellular-nanoporation method for the production of large quantities of exosomes containing therapeutic mRNAs and targeting peptides was reported, and the exosome-containing exosomal mRNA transcripts were shown to restore tumour-suppressor function, enhanced inhibition of tumour growth and increased survival.
Journal ArticleDOI
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
Stephen P.J. Fancy,Emily P. Harrington,Tracy J. Yuen,John C. Silbereis,Chao Zhao,Sergio E. Baranzini,Charlotte C. Bruce,Jose Otero,Eric J. Huang,Roel Nusse,Robin J.M. Franklin,David H. Rowitch +11 more
TL;DR: It is found that Axin2 function was essential for normal kinetics of remyelination and that it might serve as a pharmacological checkpoint in this process.
Journal ArticleDOI
β-Catenin signaling is required for neural differentiation of embryonic stem cells
TL;DR: The authors showed that β-catenin signaling is sufficient to induce neurogenesis in high-density cultures even in the absence of retinoic acid (RA), although RA potentiates the effects of β-Catenin.
Journal ArticleDOI
Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer. A multivariate study of 492 cases.
TL;DR: After radiation treatment with radical intent, recurrence at the primary site was the most frequent site of treatment failure, followed by distant metastases, whereas isolated neck recurrences occurred in only 7% of the patients.
Journal ArticleDOI
Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis
Feng Geng,Xiang Cheng,Xiaoning Wu,Ji Young Yoo,Chunming Cheng,Jeffrey Yunhua Guo,Xiaokui Mo,Peng Ru,Brian Hurwitz,Sung Hak Kim,Jose Otero,Vinay K. Puduvalli,Etienne Lefai,Jianjie Ma,Ichiro Nakano,Craig Horbinski,Balveen Kaur,Arnab Chakravarti,Deliang Guo +18 more
TL;DR: It is unraveled that cholesterol esterification and LD formation are signature of GBM, and human patients with glioma possess elevated LDs that correlate with GBM progression and poor survival, and inhibiting SOAT1 to block cholesterol Esterification is a promising therapeutic strategy to treat GBM.