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Wen Cheng Xiong
Researcher at Case Western Reserve University
Publications - 209
Citations - 13860
Wen Cheng Xiong is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Neuromuscular junction & Agrin. The author has an hindex of 64, co-authored 194 publications receiving 12171 citations. Previous affiliations of Wen Cheng Xiong include Charlie Norwood VA Medical Center & Georgia Regents University.
Papers
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Journal ArticleDOI
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei,Wen Cheng Xiong +1 more
TL;DR: An improved understanding of the mechanisms by which altered function of NRG1 and ErbB4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics.
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To build a synapse: Signaling pathways in neuromuscular junction assembly
TL;DR: This review highlights recent advances in the study of NMJ development, focusing on signaling pathways that are activated by diffusible cues, which shed light on synaptogenesis in the brain and contribute to a better understanding of muscular dystrophy.
Journal ArticleDOI
LRP4 serves as a coreceptor of agrin.
TL;DR: Observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies.
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Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses
Yang Zhong Huang,Yang Zhong Huang,Yang Zhong Huang,Sandra Won,Declan W. Ali,Qiang Wang,Qiang Wang,Qiang Wang,Michael Tanowitz,Quan S. Du,Kenneth A Pelkey,Da-Jun Yang,Wen Cheng Xiong,Michael W. Salter,Lin Mei,Lin Mei +15 more
TL;DR: NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission, suggesting that NRG signaling may be synaptic and regulated by PSD-95.
Journal ArticleDOI
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
Lei Wen,Yisheng Lu,Xin Hong Zhu,Xiao-Ming Li,Ran Sook Woo,Yong Jun Chen,Dong Min Yin,Cary Lai,Alvin V. Terry,Almira Vazdarjanova,Wen Cheng Xiong,Lin Mei +11 more
TL;DR: This study provides insight into potential pathogenic mechanisms of schizophrenia and suggests that PV-ErbB4−/− mice may serve as a model in the study of this and relevant brain disorders.