Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei,Wen Cheng Xiong +1 more
TLDR
An improved understanding of the mechanisms by which altered function of NRG1 and ErbB4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics.Abstract:
Polymorphisms in the genes that encode neuregulin 1 (NRG1) and its receptor ErbB4 have been associated with schizophrenia. Mei and Xiong review the role of NRG1 signalling in neural development and synaptic plasticity and discuss how alterations in NRG1 signalling might contribute to schizophrenia. Schizophrenia is a highly debilitating mental disorder that affects ∼1% of the general population, yet it continues to be poorly understood. Recent studies have identified variations in several genes that are associated with this disorder in diverse populations, including those that encode neuregulin 1 (NRG1) and its receptor ErbB4. The past few years have witnessed exciting progress in our knowledge of NRG1 and ErbB4 functions and the biological basis of the increased risk for schizophrenia that is potentially conferred by polymorphisms in the two genes. An improved understanding of the mechanisms by which altered function of NRG1 and ErbB4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics.read more
Citations
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Dendritic spine pathology in neuropsychiatric disorders
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Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring
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Signals of recent positive selection in a worldwide sample of human populations
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TL;DR: Analysis of recent selection in a global sample of 53 populations, using genotype data from the Human Genome Diversity-CEPH Panel, suggests that there has been selection on loci involved in susceptibility to type II diabetes.
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Animal models of schizophrenia
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