W
Wenhua Gao
Researcher at Harvard University
Publications - 13
Citations - 2877
Wenhua Gao is an academic researcher from Harvard University. The author has contributed to research in topics: Ubiquitin ligase & Isocitrate dehydrogenase. The author has an hindex of 8, co-authored 10 publications receiving 2364 citations. Previous affiliations of Wenhua Gao include Brigham and Women's Hospital & Hong Kong University of Science and Technology.
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Journal ArticleDOI
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma
Diana Miao,Diana Miao,Claire A. Margolis,Claire A. Margolis,Wenhua Gao,Martin H. Voss,Martin H. Voss,Wei Li,Dylan J. Martini,Craig Norton,Dominick Bossé,Stephanie M. Wankowicz,Stephanie M. Wankowicz,Dana Cullen,Christine Horak,Megan Wind-Rotolo,Adam Tracy,Marios Giannakis,Marios Giannakis,F.S. Hodi,Charles G. Drake,Mark W. Ball,Mohamad E. Allaf,Alexandra Snyder,Matthew D. Hellmann,Matthew D. Hellmann,Thai H. Ho,Robert J. Motzer,Robert J. Motzer,Sabina Signoretti,William G. Kaelin,William G. Kaelin,Toni K. Choueiri,Eliezer M. Van Allen,Eliezer M. Van Allen +34 more
TL;DR: Clinical benefit was associated with loss-of-function mutations in the PBRM1 gene, which encodes a subunit of the PBAF switch-sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, and may alter global tumor-cell expression profiles to influence responsiveness to immune checkpoint therapy.
Journal ArticleDOI
Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis
TL;DR: It is demonstrated that Mcl-1 is ubiquinated at five lysines, and Mule is a unique BH3-containing E3 ubiquitin ligase apical to Bcl-2 family proteins during DNA damage-induced apoptosis.
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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
TL;DR: Biochemical analysis of an apoptotic response triggered by UV irradiation of HeLa cells revealed that the elimination of cytosolic inhibitors is required for mitochondrial release of cytochrome c and subsequent caspase activation.
Journal ArticleDOI
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
Hyejin Cho,Xinlin Du,James P. Rizzi,Ella Liberzon,Abhishek A. Chakraborty,Wenhua Gao,Ingrid Carvo,Sabina Signoretti,Richard K. Bruick,John A. Josey,Wallace Eli M,William G. Kaelin,William G. Kaelin +12 more
TL;DR: It is shown that a small molecule (PT2399) that directly inhibits HIF-2α causes tumour regression in preclinical mouse models of primary and metastatic pVHL-defective clear cell renal cell carcinoma in an on-target fashion.
Journal ArticleDOI
Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells
TL;DR: Evidence is found that cytochrome c was also released before mitochondrial swelling in apoptosis induced by other cell death-inducing treatments, including tumor necrosis factor (TNF) and actinomycin D.