Wenjing Yang

TL;DR: It is shown that knocking out the P. falciparum variant-silencing SET gene (here termed PfSETvs), which encodes an orthologue of Drosophila melanogaster ASH1 and controls histone H3 lysine 36 trimethylation (H3K36me3) on var genes, results in the transcription of virtually all var genes in the single parasite nuclei and their expression as proteins on the surface of individual infected red blood cells.

TL;DR: It is found that Pol II–associated factor 1 (PAF1) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regulates the initial recruitment of PAF1 complex (PAf1C) to genes, and that the subsequent recruitment of CDK12 is dependent on PAF 1C.

TL;DR: In this paper, the role of TCF-1 and LEF1 in the CD4-versus-CD8 lineage 'choice' was mediated in part by direct positive regulation of the transcription factor Th-POK.

TL;DR: It is demonstrated that cells previously exposed to interferons exhibit a memory response and mount faster and higher transcription upon restimulation in fibroblasts and macrophages, and external signals can establish epigenetic memory in mammalian cells that imparts lasting adaptive performance upon various somatic cells.

TL;DR: This work identifies the histone H2B E3 ubiquitin ligase ring finger protein 20 (RNF20) as an additional chromatin regulator that is necessary for MLL-fusion–mediated leukemogenesis and supports a model whereby leukemia cells are dependent on Rnf20 to maintain their oncogenic transcriptional program.