Wenyi Wang

TL;DR: Factors impacting actual improvements of family-based calling, including pedigree structure, allele frequency, sequence signal-to-noise ratio, and coverage depth are studied to improve the ability to identify new disease-associated genes.

TL;DR: Despite an increased focus on radiology subspecialization, most U.S. radiologists are majority general radiologists on the basis of their work RVUs, andSubspecialization is by far more prevalent in larger and academic practices.

TL;DR: DeMixT, a new tool to deconvolve high-dimensional data from mixtures of more than two components is presented, which implements an iterated conditional mode algorithm and a novel gene-set-based component merging approach to improve accuracy.

TL;DR: A “loop” mechanism in which the JNK pathway promotes SIAH1 stabilization and in which SIAh1 in turn activates the J NK pathway and, ultimately, contributes to cell death is revealed.

TL;DR: This work extensively characterise intra-tumour heterogeneity (ITH) across 2,778 cancer whole genome sequences from 36 cancer types, demonstrating that nearly all tumours with sufficient sequencing depth contain evidence of recent subclonal expansions, and that most cancer types show clear signs of positive selection in both clonal and sub clonal protein coding variants.