W
Wenyi Wang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 123
Citations - 22012
Wenyi Wang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 28, co-authored 92 publications receiving 16322 citations. Previous affiliations of Wenyi Wang include Johns Hopkins University & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
MuSE: accounting for tumor heterogeneity using a sample-specific error model improves sensitivity and specificity in mutation calling from sequencing data
Yu Fan,Liu Xi,Daniel S.T. Hughes,Jianjun Zhang,Jianhua Zhang,P. Andrew Futreal,David A. Wheeler,Wenyi Wang +7 more
TL;DR: The accuracy of MuSE is demonstrated in calling subclonal mutations in the context of large-scale tumor sequencing projects using whole exome and whole genome sequencing.
Journal ArticleDOI
PancPRO: Risk Assessment for Individuals With a Family History of Pancreatic Cancer
TL;DR: PancPRO is the first risk prediction model for pancreatic cancer risk prediction in individuals with familial Pancreas Tumor Registry and demonstrates that accurate genetic risk assessment is possible even when the causative genes are not known.
Journal ArticleDOI
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Stefan C. Dentro,Stefan C. Dentro,Stefan C. Dentro,Ignaty Leshchiner,Kerstin Haase,Maxime Tarabichi,Maxime Tarabichi,Jeff Wintersinger,Amit G. Deshwar,Kaixian Yu,Yulia Rubanova,Geoff Macintyre,Jonas Demeulemeester,Jonas Demeulemeester,Ignacio Vázquez-García,Kortine Kleinheinz,Kortine Kleinheinz,Dimitri Livitz,Salem Malikic,Nilgun Donmez,Nilgun Donmez,Subhajit Sengupta,Pavana Anur,Clemency Jolly,Marek Cmero,Marek Cmero,Daniel Rosebrock,Steven E. Schumacher,Yu Fan,Matthew Fittall,Ruben M. Drews,Xiaotong Yao,Thomas B.K. Watkins,Juhee Lee,Matthias Schlesner,Hongtu Zhu,David J. Adams,Nicholas McGranahan,Charles Swanton,Charles Swanton,Gad Getz,Paul C. Boutros,Paul C. Boutros,Paul C. Boutros,Marcin Imielinski,Rameen Beroukhim,Rameen Beroukhim,S. Cenk Sahinalp,Yuan Ji,Yuan Ji,Martin Peifer,Inigo Martincorena,Florian Markowetz,Ville Mustonen,Ke Yuan,Ke Yuan,Moritz Gerstung,Moritz Gerstung,Paul T. Spellman,Wenyi Wang,Quaid Morris,David C. Wedge,David C. Wedge,Peter Van Loo,Santiago Gonzalez,David D.L. Bowtell,Peter J. Campbell,Shaolong Cao,Elizabeth L. Christie,Yupeng Cun,Kevin J. Dawson,Roland Eils,Dale W. Garsed,Gavin Ha,Lara Jerman,Henry Lee-Six,Thomas J. Mitchell,Layla Oesper,Myron Peto,Benjamin J. Raphael,Adriana Salcedo,Ruian Shi,Seung Jun Shin,Lincoln Stein,Oliver Spiro,Shankar Vembu,David A. Wheeler,Tsun-Po Yang +87 more
TL;DR: In this article, the authors extensively characterize intra-tumor heterogeneity (ITH) across whole-genome sequences of 2,658 cancer samples spanning 38 cancer types and identify cancer type-specific subclonal patterns of driver gene mutations, fusions, structural variants, and copy number alterations.
Posted ContentDOI
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Stefan C. Dentro,Stefan C. Dentro,Stefan C. Dentro,Ignaty Leshchiner,Kerstin Haase,Maxime Tarabichi,Maxime Tarabichi,Jeff Wintersinger,Amit G. Deshwar,Kaixian Yu,Yulia Rubanova,Geoff Macintyre,Jonas Demeulemeester,Jonas Demeulemeester,Ignacio Vázquez-García,Kortine Kleinheinz,Kortine Kleinheinz,Dimitri Livitz,Salem Malikic,Nilgun Donmez,Subhajit Sengupta,Pavana Anur,Clemency Jolly,Marek Cmero,Daniel Rosebrock,Steven E. Schumacher,Yu Fan,Matthew Fittall,Ruben M. Drews,Xiaotong Yao,Juhee Lee,Matthias Schlesner,Hongtu Zhu,David J. Adams,Gad Getz,Paul C. Boutros,Paul C. Boutros,Marcin Imielinski,Rameen Beroukhim,S. Cenk Sahinalp,Yuan Ji,Yuan Ji,Martin Peifer,Inigo Martincorena,Florian Markowetz,Ville Mustonen,Ke Yuan,Ke Yuan,Moritz Gerstung,Paul T. Spellman,Wenyi Wang,Quaid Morris,David C. Wedge,Peter Van Loo +53 more
TL;DR: The results underline the importance of ITH and its drivers in tumor evolution, and provide an unprecedented pan-cancer resource of comprehensively annotated subclonal events from whole-genome sequencing data.
Journal ArticleDOI
Proteogenomic characterization of pancreatic ductal adenocarcinoma
Liwei Cao,Chen Huang,Daniel Cui Zhou,Yingwei Hu,T. Mamie Lih,Sara R. Savage,Karsten Krug,David J. Clark,Michael Schnaubelt,Lijun Chen,Felipe da Veiga Leprevost,Rodrigo Vargas Eguez,Weiming Yang,Jianbo Pan,Bo Wen,Yongchao Dou,Wen Jiang,Yuxing Liao,Zhiao Shi,Nadezhda V. Terekhanova,Song Cao,Rita Jui-Hsien Lu,Yize Li,Ruiyang Liu,Houxiang Zhu,Peter Ronning,Yige Wu,Matthew A. Wyczalkowski,Hariharan Easwaran,Ludmila Danilova,Arvind Singh Mer,Seungyeul Yoo,Joshua M. Wang,Wenke Liu,Benjamin Haibe-Kains,Benjamin Haibe-Kains,Mathangi Thiagarajan,Scott D. Jewell,Galen Hostetter,Chelsea J. Newton,Qing Kay Li,Michael H.A. Roehrl,David Fenyö,Pei Wang,Alexey I. Nesvizhskii,D. R. Mani,Gilbert S. Omenn,Emily S. Boja,Mehdi Mesri,Ana I. Robles,Henry Rodriguez,Oliver F. Bathe,Daniel W. Chan,Ralph H. Hruban,Li Ding,Bing Zhang,Hui Zhang,Mitual Amin,Eunkyung An,Christina Ayad,Thomas L. Bauer,Chet Birger,Michael J. Birrer,Simina M. Boca,William Bocik,Melissa Borucki,Shuang Cai,Steven A. Carr,Sandra Cerda,Huan Chen,Steven Chen,David Chesla,Arul M. Chinnaiyan,Antonio Colaprico,Sandra Cottingham,Magdalena Derejska,Saravana M. Dhanasekaran,Marcin J. Domagalski,Brian J. Druker,Elizabeth R. Duffy,Maureen Dyer,Nathan Edwards,Matthew J. Ellis,Jennifer M. Eschbacher,Alicia Francis,Jesse Francis,Stacey Gabriel,Nikolay Gabrovski,Johanna Gardner,Gad Getz,Michael A. Gillette,Charles A. Goldthwaite,Pamela Grady,Shuai Guo,Pushpa Hariharan,Tara Hiltke,Barbara Hindenach,Katherine A. Hoadley,Jasmine Huang,Corbin D. Jones,Karen A. Ketchum,Christopher R. Kinsinger,Jennifer M. Koziak,Katarzyna Kusnierz,Tao Liu,Jiang Long,David Mallery,Sailaja Mareedu,Ronald Matteotti,Nicollette Maunganidze,Peter B. McGarvey,Parham Minoo,Oxana Paklina,Amanda G. Paulovich,Samuel H. Payne,Olga Potapova,Barbara Pruetz,Liqun Qi,Nancy Roche,Karin D. Rodland,Daniel C. Rohrer,Eric E. Schadt,Alexey Shabunin,Troy Shelton,Yvonne Shutack,Shilpi Singh,Michael Smith,Richard D. Smith,Lori J. Sokoll,James Suh,Ratna R. Thangudu,Shirley Tsang,Ki Sung Um,Dana R. Valley,Negin Vatanian,Wenyi Wang,George D. Wilson,Maciej Wiznerowicz,Zhen Zhang,Grace Zhao +139 more
TL;DR: In this article, a comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 normal pancreatic ductal tissues was conducted to understand the underlying molecular alterations that drive PDAC oncogenesis.