Whitney E. Harrington

TL;DR: Diverse microbial pathogens were identified by mNGS in the CSF of patients with diagnostically challenging subacute or chronic meningitis, including a case of subarachnoid neurocysticercosis that defied diagnosis for 1 year, and the first reported case of CNS vasculitis caused by Aspergillus oryzae.

TL;DR: A semiquantitative pathological grading scheme is simple to implement and captures information that is associated with outcomes in Asia and Africa; therefore, it should facilitate the comparison and standardization of results among clinical trials across areas of differing endemicity.

TL;DR: Cost-benefit analyses of IPTp regimens should consider the long term effects on offspring in addition to pregnancy outcomes, as these effects are likely to be significant over the long-term.

Abstract: The fate of protective immunity following mild SARS-CoV-2 infection remains ill defined Here we characterize antibody responses in a cohort of participants recovered from mild SARS-CoV-2 infection with follow up to 6 months We measure IgA, IgM, and IgG binding and avidity to viral antigens and assess neutralizing antibody responses over time Further, we correlate the effect of fever, gender, age, and time since symptom onset with antibody responses We observe that total anti-S trimer, anti-RBD, and anti-NP IgG are relatively stable over 6 months of follow-up and anti-S and anti-RBD avidity increases over time, and that fever is associated with higher levels of antibodies However, neutralizing antibody responses rapidly decay and are strongly associated with declines in IgM levels Thus, while total antibody against SARS-CoV-2 may persist, functional antibody, particularly IgM, is rapidly lost These observations have implications for the duration of protective immunity following mild SARS-CoV-2 infection

TL;DR: Levels and phenotypes of CB MMc with potential relevance to CB transplantation and, more broadly, to offspring health are revealed, including in memory T cells than other subsets.